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Mapkapk3 mitogen-activated protein kinase-activated protein kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 102626, updated on 21-Apr-2024

Summary

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Official Symbol
Mapkapk3provided by MGI
Official Full Name
mitogen-activated protein kinase-activated protein kinase 3provided by MGI
Primary source
MGI:MGI:2143163
See related
Ensembl:ENSMUSG00000032577 AllianceGenome:MGI:2143163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3PK; MK3; MK-3; MAPKAP3; MAPKAP-K3; MapkKapk3
Summary
Predicted to enable calmodulin binding activity; mitogen-activated protein kinase binding activity; and protein serine/threonine kinase activity. Involved in macropinocytosis; response to lipopolysaccharide; and toll-like receptor signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; naris; skin; urinary system; and ventral grey horn. Human ortholog(s) of this gene implicated in patterned macular dystrophy 3. Orthologous to human MAPKAPK3 (MAPK activated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 18.4), bladder adult (RPKM 12.5) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F1; 9 57.98 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107132125..107167082, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107254927..107289877, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene dedicator of cyto-kinesis 3 Neighboring gene myc-like oncogene, s-myc protein pseudogene Neighboring gene predicted gene, 51734 Neighboring gene STARR-seq mESC enhancer starr_25168 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107192213-107192396 Neighboring gene STARR-positive B cell enhancer mm9_chr9:107198795-107199096 Neighboring gene predicted gene 17040 Neighboring gene cytokine inducible SH2-containing protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of a novel MK3 splice variant from murine ventricular myocardium. Moïse N, et al. Cell Signal, 2010 Oct. PMID 20570725, Free PMC Article
  2. Pharmacological and genetic inhibition of downstream targets of p38 MAPK in experimental nephrotic syndrome. Nie X, et al. Am J Physiol Renal Physiol, 2018 Apr 1. PMID 29187369, Free PMC Article
  3. MK2/3 Are Pivotal for IL-33-Induced and Mast Cell-Dependent Leukocyte Recruitment and the Resulting Skin Inflammation. Drube S, et al. J Immunol, 2016 Nov 1. PMID 27694493
  4. A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium. Meunier I, et al. Hum Mol Genet, 2016 Mar 1. PMID 26744326
  5. MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection. Köther K, et al. FASEB J, 2014 Oct. PMID 24935968, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-33-activated murine mast cells control the dichotomy between RORgammat(+) and Helios(+) Tregs via the MK2/3-mediated IL-6 production in vitro
    Title: IL-33-activated murine mast cells control the dichotomy between RORγt(+) and Helios(+) T(regs) via the MK2/3-mediated IL-6 production in vitro.
  2. The MK2/3 are the only LPS-induced kinases for S52 and S178 of TTP and the role of MK2 and MK3 in the regulation of TNF biosynthesis is not restricted to phosphorylation of TTP at S52/S178 but includes independent processes, which could involve other TTP phosphorylations.
    Title: The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3.
  3. this study shows that the loss of MK3 in mast cells decreases the IL-33-induced leukocyte recruitment and the resulting skin inflammation
    Title: MK2/3 Are Pivotal for IL-33-Induced and Mast Cell-Dependent Leukocyte Recruitment and the Resulting Skin Inflammation.
  4. A dominant mutation in MAPKAPK3 causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium.
    Title: A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium.
  5. MK2/3 cascade plays a strategic role in controlling synaptic plasticity and cognition.
    Title: The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility.
  6. This study showed that cmpd28, a Mapkapk2/3 inhibitor, represents a potentially new approach to type 2 diabetes therapy.
    Title: Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity.
  7. Mk3-/- mice, challenged with IAV infection, show a strong shift toward an innate NK cell and adaptive Th1 immune response and a resistance to influenza.
    Title: MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection.
  8. MAPKAPK-3 regulates SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function.
    Title: Mitogen-activated protein kinase-activated protein kinases 2 and 3 regulate SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function.
  9. Protein kinases MK2 and MK3 play critical roles in a mouse model of glomerulonephritis.
    Title: Crucial roles of the protein kinases MK2 and MK3 in a mouse model of glomerulonephritis.
  10. MK2 regulates LPS-induced IFNbeta expression and downstream STAT3 activation as it restrains MK3 from mediating negative regulatory effects
    Title: Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macropinocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to cytokine ISO
Inferred from Sequence Orthology
more info
  
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MAP kinase-activated protein kinase 3
Names
MAPK-activated protein kinase 3
MAPKAP kinase 3
MAPKAPK-3
NP_001303620.1
NP_001408254.1
NP_849238.1
XP_006511680.1
XP_006511681.1
XP_006511682.1
XP_036010401.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316691.2 → NP_001303620.1  MAP kinase-activated protein kinase 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two consecutive coding exons in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. This variant is described in PMID:20570725.
    Source sequence(s)
    AL672070
    Consensus CDS
    CCDS85722.1
    UniProtKB/TrEMBL
    Q09HN3
    Related
    ENSMUSP00000141342.2, ENSMUST00000192054.2
    Conserved Domains (2) summary
    smart00220
    Location:45 → 237
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:41 → 258
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001421325.1 → NP_001408254.1  MAP kinase-activated protein kinase 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672070
    UniProtKB/Swiss-Prot
    B0QZU7, E9QNE1, Q3T9E6, Q3UMW7, Q8K0G3

  3. NM_178907.4 → NP_849238.1  MAP kinase-activated protein kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_849238.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL672070
    Consensus CDS
    CCDS23487.1
    UniProtKB/Swiss-Prot
    B0QZU7, E9QNE1, Q3T9E6, Q3UMW7, Q8K0G3
    Related
    ENSMUSP00000035194.3, ENSMUST00000035194.8
    Conserved Domains (1) summary
    cl21453
    Location:41 → 306
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107132125..107167082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154508.1 → XP_036010401.1  MAP kinase-activated protein kinase 3 isoform X4

    UniProtKB/TrEMBL
    Q09HN3
    Conserved Domains (1) summary
    cl21453
    Location:41 → 288
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006511618.5 → XP_006511681.1  MAP kinase-activated protein kinase 3 isoform X3

    Conserved Domains (1) summary
    cd14089
    Location:10 → 244
    STKc_MAPKAPK; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases

  3. XM_006511619.3 → XP_006511682.1  MAP kinase-activated protein kinase 3 isoform X5

    Conserved Domains (1) summary
    cl21453
    Location:1 → 197
    PKc_like; Protein Kinases, catalytic domain

  4. XM_006511617.5 → XP_006511680.1  MAP kinase-activated protein kinase 3 isoform X2

    Conserved Domains (1) summary
    cd14089
    Location:20 → 249
    STKc_MAPKAPK; Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UMW7.2 GenPept UniProtKB/Swiss-Prot:Q3UMW7

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