U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dcun1d2 defective in cullin neddylation 1 domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 102323, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Dcun1d2provided by MGI
Official Full Name
defective in cullin neddylation 1 domain containing 2provided by MGI
Primary source
MGI:MGI:2142792
See related
Ensembl:ENSMUSG00000038506 AllianceGenome:MGI:2142792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DCNL2; mFLJ10704
Summary
Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in positive regulation of protein neddylation; positive regulation of ubiquitin-protein transferase activity; and protein neddylation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ubiquitin ligase complex. Orthologous to human DCUN1D2 (defective in cullin neddylation 1 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 17.4), cerebellum adult (RPKM 12.6) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
8 A1.1; 8 5.73 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13305963..13337833, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13255963..13288126, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810030D12 gene Neighboring gene STARR-seq mESC enhancer starr_20764 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:13213467-13213836 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:13213972-13214173 Neighboring gene ADP-ribosylhydrolase like 1 Neighboring gene predicted gene, 25014 Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene STARR-positive B cell enhancer ABC_E6621 Neighboring gene transcription factor Dp 1 Neighboring gene ATPase, H+/K+ exchanging, beta polypeptide

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Kurz T, et al. Nature, 2005 Jun 30. PMID 15988528
  2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein neddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein neddylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
DCN1-like protein 2
Names
DCN1, defective in cullin neddylation 1, domain containing 2
DCUN1 domain-containing protein 2
defective in cullin neddylation protein 1-like protein 2
squamous cell carcinoma-related oncogene 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024504.3 → NP_001019675.2  DCN1-like protein 2 isoform a

    See identical proteins and their annotated locations for NP_001019675.2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    Consensus CDS
    CCDS40228.1
    UniProtKB/Swiss-Prot
    Q3U1U0, Q7TMX3, Q8BZJ7
    Related
    ENSMUSP00000047208.8, ENSMUST00000045366.10
    Conserved Domains (2) summary
    pfam03556
    Location:137 → 247
    Cullin_binding; Cullin binding
    cl21463
    Location:2 → 48
    UBA_like_SF; UBA domain-like superfamily

  2. NM_001042649.2 → NP_001036114.1  DCN1-like protein 2 isoform c

    See identical proteins and their annotated locations for NP_001036114.1

    Status: VALIDATED

    Source sequence(s)
    AC130818
    Consensus CDS
    CCDS40230.1
    UniProtKB/TrEMBL
    G5E8Q5, Q3TSY8
    Related
    ENSMUSP00000106462.2, ENSMUST00000110838.8
    Conserved Domains (2) summary
    pfam03556
    Location:137 → 173
    Cullin_binding; Cullin binding
    cl21463
    Location:2 → 48
    UBA_like_SF; UBA domain-like superfamily

  3. NM_001042650.2 → NP_001036115.1  DCN1-like protein 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC130818
    Consensus CDS
    CCDS40227.1
    UniProtKB/TrEMBL
    Q3TSY8
    Related
    ENSMUSP00000106464.2, ENSMUST00000110840.8
    Conserved Domains (2) summary
    pfam03556
    Location:137 → 187
    Cullin_binding; Cullin binding
    cl21463
    Location:2 → 48
    UBA_like_SF; UBA domain-like superfamily

  4. NM_001042651.2 → NP_001036116.1  DCN1-like protein 2 isoform b

    See identical proteins and their annotated locations for NP_001036116.1

    Status: VALIDATED

    Source sequence(s)
    AC130818
    Consensus CDS
    CCDS40229.1
    UniProtKB/TrEMBL
    G5E8Q6, Q3TSY8
    Related
    ENSMUSP00000106463.4, ENSMUST00000110839.10
    Conserved Domains (2) summary
    pfam03556
    Location:137 → 203
    Cullin_binding; Cullin binding
    cl21463
    Location:2 → 48
    UBA_like_SF; UBA domain-like superfamily

  5. NM_001426633.1 → NP_001413562.1  DCN1-like protein 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC130818

  6. NM_001426634.1 → NP_001413563.1  DCN1-like protein 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC130818

  7. NM_001426635.1 → NP_001413564.1  DCN1-like protein 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC130818

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    13305963..13337833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZJ7.3 GenPept UniProtKB/Swiss-Prot:Q8BZJ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous