ADAM10 ADAM metallopeptidase domain 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADAM10provided by HGNC
Official Full Name: ADAM metallopeptidase domain 10provided by HGNC
Primary source: HGNC:HGNC:188
See related: Ensembl:ENSG00000137845 MIM:602192; AllianceGenome:HGNC:188
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAK; kuz; AD10; AD18; MADM; CD156c; CDw156; HsT18717
Summary: Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]
Expression: Ubiquitous expression in urinary bladder (RPKM 30.9), thyroid (RPKM 26.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q21.3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (58588809..58749707, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (56390788..56551686, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (58881008..59041906, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4/ADAM10/CX3CL1 axis.
Title: Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4/ADAM10/CX3CL1 axis.
Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis.
Title: Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis.
ADAM10 as a biomarker for Alzheimer's disease: A systematic review.
Title: ADAM10 as a biomarker for Alzheimer's disease: A systematic review.
Proteolytic cleavage of amyloid precursor protein by ADAM10 promotes proliferation and migration via activating MAPKs pathway in tongue squamous cell carcinoma in vitro.
Title: Proteolytic cleavage of amyloid precursor protein by ADAM10 promotes proliferation and migration via activating MAPKs pathway in tongue squamous cell carcinoma in vitro.
NCK1-AS1 promotes the proliferation, migration, invasion, and EMT of non-small cell lung cancer by regulating the miR-361-5p/ADAM10 axis.
Title: NCK1-AS1 promotes the proliferation, migration, invasion, and EMT of non-small cell lung cancer by regulating the miR-361-5p/ADAM10 axis.
Tissue inhibitors of metalloproteinases (TIMPs) modulate platelet ADAM10 activity.
Title: Tissue inhibitors of metalloproteinases (TIMPs) modulate platelet ADAM10 activity.
Characterizing the transmembrane domains of ADAM10 and BACE1 and the impact of membrane composition.
Title: Characterizing the transmembrane domains of ADAM10 and BACE1 and the impact of membrane composition.
AMPK boosts ADAM10 shedding activity in human aortic endothelial cells by promoting Rab14-dependent ADAM10 cell surface translocation.
Title: AMPK boosts ADAM10 shedding activity in human aortic endothelial cells by promoting Rab14-dependent ADAM10 cell surface translocation.
Structural basis for membrane-proximal proteolysis of substrates by ADAM10.
Title: Structural basis for membrane-proximal proteolysis of substrates by ADAM10.
Combined proteomics and CRISPR-Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo.
Title: Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (329)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Alzheimer disease 18 MedGen: C3810041 OMIM: 615590 GeneReviews: Not available	Compare labs
Reticulate acropigmentation of Kitamura MedGen: C0406811 OMIM: 615537 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infected clinical samples have plasma extracellular vesicles that contain elevated ADAM10, ADAM17, and TNF when compared to healthy donors	PubMed
Knockdown of ADAM metallopeptidase domain 10 (ADAM10) by siRNA inhibits HIV-1 replication in CD4+ T lymphocytes	PubMed
Knockdown of ADAM metallopeptidase domain 10 (ADAM10) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 interacts with ADAM10; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix	PubMed
Nef	nef	HIV-1 Nef associates with ADAM10 in extracellular vesicles isolated from HIV-1-infected patients	PubMed
Pr55(Gag)	gag	Treatment of PBMCs taken from treatment-naive HIV chronically infected individuals with a HIV-1 Gag peptide pool in the presence of ADAM10 inhibitor upregulates the levels of Tim-3 and IFN-gamma in CD8+ T cells	PubMed
integrase	gag-pol	HIV-1 IN co-localizes and co-immunoprecipitates with ADAM10 in U373 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adam10 (e-PCR), detects polymorphism
- UniSTS:471063

RH45136 (e-PCR)
- UniSTS:11815

D15S686E (e-PCR)
- UniSTS:151596

RH45644 (e-PCR)
- UniSTS:30268

D15S1248 (e-PCR)
- UniSTS:1613

A002R12 (e-PCR)
- UniSTS:61783

RH17532 (e-PCR)
- UniSTS:65890

SHGC-150627 (e-PCR)
- UniSTS:173188

G32289 (e-PCR)
- UniSTS:116886

ADAM10 (e-PCR)
- UniSTS:277931

D15S148 (e-PCR), detects polymorphism
- UniSTS:13751

D15S148 (e-PCR), detects polymorphism
- UniSTS:13752

RH66959 (e-PCR)
- UniSTS:85441

RH45709 (e-PCR)
- UniSTS:31962

ADAM10_1576 (e-PCR)
- UniSTS:276960

ADAM10_v552 (e-PCR)
- UniSTS:276960

SHGC-81261 (e-PCR)
- UniSTS:102390

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables integrin binding	NAS Non-traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallodipeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metalloendopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metalloendopeptidase activity	NAS Non-traceable Author Statement more info	PubMed
enables metalloendopeptidase activity	TAS Traceable Author Statement more info
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
enables metallopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables molecular adaptor activity	EXP Inferred from Experiment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adherens junction organization	IEA Inferred from Electronic Annotation more info
involved_in amyloid precursor protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid precursor protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in cochlea development	IEA Inferred from Electronic Annotation more info
involved_in constitutive protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor ligand maturation	IEA Inferred from Electronic Annotation more info
involved_in extracellular matrix disassembly	TAS Traceable Author Statement more info
involved_in in utero embryonic development	ISS Inferred from Sequence or Structural Similarity more info
involved_in integrin-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane protein ectodomain proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monocyte activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell adhesion	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pore complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in protein catabolic process at postsynapse	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of vasculature development	IEA Inferred from Electronic Annotation more info
involved_in response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in focal adhesion	HDA more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in membrane	HDA more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of pore complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in specific granule membrane	TAS Traceable Author Statement more info
is_active_in synaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in tertiary granule membrane	TAS Traceable Author Statement more info
located_in tetraspanin-enriched microdomain	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 10

Names: a disintegrin and metalloprotease domain 10; kuzbanian protein homolog; mammalian disintegrin-metalloprotease

NP_001101.1

EC 3.4.24.81

NP_001307499.1

EC 3.4.24.81

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033876.2 RefSeqGene

Range

5001..165899

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001110.4 → NP_001101.1 disintegrin and metalloproteinase domain-containing protein 10 isoform 1 preproprotein

See identical proteins and their annotated locations for NP_001101.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AA243020, AC018904, AF009615, AY726599, BE327886, BX372217, DA941750

Consensus CDS

CCDS10167.1

UniProtKB/Swiss-Prot

B4DU28, O14672, Q10742, Q92650

Related

ENSP00000260408.3, ENST00000260408.8

Conserved Domains (3) summary

smart00050
Location:466 → 545

DISIN; Homologues of snake disintegrins

cd04270
Location:220 → 459

ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.

pfam01562
Location:46 → 156

Pep_M12B_propep; Reprolysin family propeptide
NM_001320570.2 → NP_001307499.1 disintegrin and metalloproteinase domain-containing protein 10 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.

Source sequence(s)

AC018904, AC091046

Conserved Domains (3) summary

smart00050
Location:435 → 514

DISIN; Homologues of snake disintegrins

cd04270
Location:220 → 428

ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.

pfam01562
Location:43 → 156

Pep_M12B_propep; Reprolysin family propeptide