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OPHN1 oligophrenin 1 [ Ovis aries (sheep) ]

Gene ID: 101120140, updated on 3-Apr-2024

Summary

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Gene symbol
OPHN1
Gene description
oligophrenin 1
See related
EnsemblRapid:ENSOARG00020020275
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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See OPHN1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) X NC_056080.1 (60621040..61337725, complement)

Chromosome X - NC_056080.1Genomic Context describing neighboring genes Neighboring gene transfer RNA tyrosine (anticodon GUA) Neighboring gene androgen receptor Neighboring gene small nucleolar RNA SNORA79 Neighboring gene uncharacterized LOC132658727 Neighboring gene U6 spliceosomal RNA Neighboring gene Yip1 domain family member 6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056080.1 Chromosome X Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
oligophrenin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056080.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    60621040..61337725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_060407314.1 → XP_060263297.1  oligophrenin-1 isoform X6

  2. XM_060407309.1 → XP_060263292.1  oligophrenin-1 isoform X4

  3. XM_060407304.1 → XP_060263287.1  oligophrenin-1 isoform X2

  4. XM_060407302.1 → XP_060263285.1  oligophrenin-1 isoform X1

  5. XM_060407331.1 → XP_060263314.1  oligophrenin-1 isoform X19

  6. XM_060407313.1 → XP_060263296.1  oligophrenin-1 isoform X6

  7. XM_060407308.1 → XP_060263291.1  oligophrenin-1 isoform X4

  8. XM_060407334.1 → XP_060263317.1  oligophrenin-1 isoform X21

  9. XM_060407319.1 → XP_060263302.1  oligophrenin-1 isoform X10

  10. XM_060407318.1 → XP_060263301.1  oligophrenin-1 isoform X9

  11. XM_060407326.1 → XP_060263309.1  oligophrenin-1 isoform X16

  12. XM_060407325.1 → XP_060263308.1  oligophrenin-1 isoform X15

  13. XM_060407303.1 → XP_060263286.1  oligophrenin-1 isoform X2

    Related
    ENSOARP00020025772.2, ENSOART00020031200.2

  14. XM_060407301.1 → XP_060263284.1  oligophrenin-1 isoform X1

  15. XM_060407323.1 → XP_060263306.1  oligophrenin-1 isoform X13

  16. XM_060407305.1 → XP_060263288.1  oligophrenin-1 isoform X3

  17. XM_060407312.1 → XP_060263295.1  oligophrenin-1 isoform X5

    UniProtKB/TrEMBL
    A0A6P7DL19, W5PYY3
    Related
    ENSOARP00020025962.2, ENSOART00020031411.2

  18. XM_060407330.1 → XP_060263313.1  oligophrenin-1 isoform X18

  19. XM_060407328.1 → XP_060263311.1  oligophrenin-1 isoform X17

  20. XM_060407311.1 → XP_060263294.1  oligophrenin-1 isoform X5

    UniProtKB/TrEMBL
    A0A6P7DL19, W5PYY3

  21. XM_060407306.1 → XP_060263289.1  oligophrenin-1 isoform X3

  22. XM_060407307.1 → XP_060263290.1  oligophrenin-1 isoform X3

  23. XM_060407324.1 → XP_060263307.1  oligophrenin-1 isoform X14

  24. XM_060407333.1 → XP_060263316.1  oligophrenin-1 isoform X20

  25. XM_060407317.1 → XP_060263300.1  oligophrenin-1 isoform X8

  26. XM_060407315.1 → XP_060263298.1  oligophrenin-1 isoform X7

  27. XM_060407336.1 → XP_060263319.1  oligophrenin-1 isoform X22

  28. XM_060407322.1 → XP_060263305.1  oligophrenin-1 isoform X12

  29. XM_042242393.2 → XP_042098327.1  oligophrenin-1 isoform X11

    Conserved Domains (4) summary
    cd07633
    Location:19 → 225
    BAR_OPHN1; The Bin/Amphiphysin/Rvs (BAR) domain of Oligophrenin-1
    PHA03247
    Location:511 → 725
    PHA03247; large tegument protein UL36; Provisional
    cd01249
    Location:267 → 371
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:364 → 505
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  30. XM_060407329.1 → XP_060263312.1  oligophrenin-1 isoform X18

  31. XM_060407327.1 → XP_060263310.1  oligophrenin-1 isoform X17

  32. XM_060407310.1 → XP_060263293.1  oligophrenin-1 isoform X5

    UniProtKB/TrEMBL
    A0A6P7DL19, W5PYY3

  33. XM_042242391.2 → XP_042098325.1  oligophrenin-1 isoform X3

    Conserved Domains (4) summary
    cd07633
    Location:19 → 225
    BAR_OPHN1; The Bin/Amphiphysin/Rvs (BAR) domain of Oligophrenin-1
    PHA03247
    Location:566 → 780
    PHA03247; large tegument protein UL36; Provisional
    cd04374
    Location:364 → 560
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:267 → 371
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

  34. XM_060407332.1 → XP_060263315.1  oligophrenin-1 isoform X20

  35. XM_060407316.1 → XP_060263299.1  oligophrenin-1 isoform X8

  36. XM_042242392.2 → XP_042098326.1  oligophrenin-1 isoform X7

    Conserved Domains (4) summary
    PHA03247
    Location:542 → 756
    PHA03247; large tegument protein UL36; Provisional
    cd04374
    Location:340 → 536
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:243 → 347
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:19 → 201
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  37. XM_060407335.1 → XP_060263318.1  oligophrenin-1 isoform X22

  38. XM_060407321.1 → XP_060263304.1  oligophrenin-1 isoform X12

    Related
    ENSOARP00020026475.2, ENSOART00020032054.2

  39. XM_060407320.1 → XP_060263303.1  oligophrenin-1 isoform X11

  40. XM_042242396.2 → XP_042098330.1  oligophrenin-1 isoform X18

    UniProtKB/TrEMBL
    A0A835ZH62
    Related
    ENSOARP00020026618.1, ENSOART00020032229.2
    Conserved Domains (3) summary
    cd07633
    Location:19 → 225
    BAR_OPHN1; The Bin/Amphiphysin/Rvs (BAR) domain of Oligophrenin-1
    cd04374
    Location:364 → 560
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:267 → 371
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

  41. XM_027963583.3 → XP_027819384.1  oligophrenin-1 isoform X5

    UniProtKB/TrEMBL
    A0A6P7DL19, W5PYY3
    Related
    ENSOARP00020026116.1, ENSOART00020031595.2

  42. XM_042242390.2 → XP_042098324.1  oligophrenin-1 isoform X3

    Conserved Domains (4) summary
    cd07633
    Location:19 → 225
    BAR_OPHN1; The Bin/Amphiphysin/Rvs (BAR) domain of Oligophrenin-1
    PHA03247
    Location:566 → 780
    PHA03247; large tegument protein UL36; Provisional
    cd04374
    Location:364 → 560
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:267 → 371
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
Nucleotide Protein Strain
Heading Accession and Version

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