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Chpf2 chondroitin polymerizing factor 2 [ Mus musculus (house mouse) ]

Gene ID: 100910, updated on 21-Apr-2024

Summary

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Official Symbol
Chpf2provided by MGI
Official Full Name
chondroitin polymerizing factor 2provided by MGI
Primary source
MGI:MGI:1917522
See related
Ensembl:ENSMUSG00000038181 AllianceGenome:MGI:1917522
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm42230; mir-671; mKIAA1402; 2010209O12Rik
Summary
Predicted to enable glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Predicted to be involved in chondroitin sulfate biosynthetic process. Orthologous to human CHPF2 (chondroitin polymerizing factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 27.5), ovary adult (RPKM 21.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5; 5 A3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24788950..24799396)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24586744..24594398)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6314 Neighboring gene ATP-binding cassette, sub-family F member 2 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Neighboring gene microRNA 671 Neighboring gene glycerol-3-phosphate dehydrogenase 1-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_12645 Neighboring gene STARR-positive B cell enhancer mm9_chr5:24180078-24180378 Neighboring gene STARR-positive B cell enhancer ABC_E1298 Neighboring gene STARR-positive B cell enhancer ABC_E11722 Neighboring gene negative regulator of ubiquitin-like proteins 1 Neighboring gene WD repeat domain 86

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members. Izumikawa T, et al. J Biol Chem, 2008 Apr 25. PMID 18316376
  2. Biosynthesis of chondroitin sulphate by a Golgi-apparatus-enriched preparation from cultures of mouse mastocytoma cells. Silbert JE, et al. Biochem J, 1980 Aug 15. PMID 6781479, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  5. miRBase: integrating microRNA annotation and deep-sequencing data. Kozomara A, et al. Nucleic Acids Res, 2011 Jan. PMID 21037258, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chondroitin sulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chondroitin sulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
chondroitin sulfate glucuronyltransferase
NP_598674.2
XP_036020598.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133913.2 → NP_598674.2  chondroitin sulfate glucuronyltransferase precursor

    See identical proteins and their annotated locations for NP_598674.2

    Status: VALIDATED

    Source sequence(s)
    AK122504, BC036970
    Consensus CDS
    CCDS51436.1
    UniProtKB/TrEMBL
    Q3UU43, Q80TE1
    Related
    ENSMUSP00000112804.2, ENSMUST00000121863.5
    Conserved Domains (2) summary
    pfam05679
    Location:242 → 755
    CHGN; Chondroitin N-acetylgalactosaminyltransferase
    cl21608
    Location:177 → 269
    Galactosyl_T; Galactosyltransferase

RNA

  1. NR_155297.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116136, AK138814, BE854619

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    24788950..24799396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164705.1 → XP_036020598.1  chondroitin sulfate glucuronyltransferase isoform X1

    UniProtKB/TrEMBL
    Q3UU43, Q80TE1
    Related
    ENSMUSP00000085633.5, ENSMUST00000088295.9
    Conserved Domains (2) summary
    pfam05679
    Location:242 → 755
    CHGN; Chondroitin N-acetylgalactosaminyltransferase
    cl21608
    Location:177 → 269
    Galactosyl_T; Galactosyltransferase
Nucleotide Protein Strain
Heading Accession and Version

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