APOBEC3C apolipoprotein B mRNA editing enzyme catalytic subunit 3C [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: APOBEC3Cprovided by VGNC
Official Full Name: apolipoprotein B mRNA editing enzyme catalytic subunit 3Cprovided by VGNC
Primary source: VGNC:VGNC:6686
See related: Ensembl:ENSPTRG00000014384
Gene type: protein coding
RefSeq status: INFERRED
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
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Genomic context

Location:: chromosome: 22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	23	NC_086016.1 (41017043..41021576)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	22	NC_072420.1 (34049438..34053971)

Chromosome 23 - NC_086016.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cytidine deaminase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables deoxycytidine deaminase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA cytosine deamination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in DNA demethylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cytidine to uridine editing	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: DNA dC->dU-editing enzyme APOBEC-3C

Names: apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C; probable DNA dC->dU-editing enzyme APOBEC-3C

NP_001238839.1

EC 3.5.4.38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001251910.2 → NP_001238839.1 DNA dC->dU-editing enzyme APOBEC-3C

See identical proteins and their annotated locations for NP_001238839.1

Status: INFERRED

Source sequence(s)

DC529080, JAQQLN020000023

UniProtKB/TrEMBL

H2QLP6, K7CK26

Related

ENSPTRP00000024779.4, ENSPTRT00000026880.5

Conserved Domains (3) summary

cd01283
Location:8 → 158

cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...

pfam05240
Location:129 → 174

APOBEC_C; APOBEC-like C-terminal domain

pfam08210
Location:17 → 187

APOBEC_N; APOBEC-like N-terminal domain