CDH2 cadherin 2 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: CDH2provided by VGNC
Official Full Name: cadherin 2provided by VGNC
Primary source: VGNC:VGNC:86483
See related: Ensembl:ENSSSCG00000003722
Gene type: protein coding
RefSeq status: MODEL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Biased expression in heart (RPKM 98.3), spleen (RPKM 41.1) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	6	NC_010448.4 (112396713..112629073, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	6	NC_010448.3 (105317507..105518900, complement)

Chromosome 6 - NC_010448.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The noncompressed discs were used as controls. Compared with the dynamic compression, static compression significantly down-regulated the expression of N-CDH and NP-specific markers (laminin, brachyury, and keratin 19); decreased the Alcian Blue staining intensity, glycosaminoglycan and hydroxyproline contents; and declined the matrix macromolecule (aggrecan and collagen II) expression
Title: Static compression down-regulates N-cadherin expression and facilitates loss of cell phenotype of nucleus pulposus cells in a disc perfusion culture.
Long-term load duration can induce N-cadherin down-regulation, loss of normal cell phenotype and result in attenuation of nucleus pulposus - related matrix synthesis in nucleus pulposus cells.
Title: Long-term load duration induces N-cadherin down-regulation and loss of cell phenotype of nucleus pulposus cells in a disc bioreactor culture.
Asymmetrical distribution of N-cadherin is necessary for the establishment of cell polarity during migration and that N-cadherin ligation is highly effective in abrogating polarized migration.
Title: Homotypic and endothelial cell adhesions via N-cadherin determine polarity and regulate migration of vascular smooth muscle cells.

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General gene information

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Markers

REN15257 (e-PCR)
- UniSTS:340057

REN15258 (e-PCR)
- UniSTS:340058

REN16026 (e-PCR)
- UniSTS:340826

stSG624268 (e-PCR)
- UniSTS:455824

ECD13519 (e-PCR)
- UniSTS:294548

REN15626 (e-PCR)
- UniSTS:340426

REN15918 (e-PCR)
- UniSTS:340718

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cadherin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adherens junction organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in brain development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell junction assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of axonogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info	PubMed
involved_in synapse assembly	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info	PubMed
located_in apical part of cell	IEA Inferred from Electronic Annotation more info	PubMed
part_of catenin complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in intercalated disc	IEA Inferred from Electronic Annotation more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info	PubMed
located_in postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in presynaptic active zone membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cadherin-2

Names: cadherin 2, type 1, N-cadherin (neuronal)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010448.4 Reference Sscrofa11.1 Primary Assembly

Range

112396713..112629073 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021096205.1 → XP_020951864.1 cadherin-2

UniProtKB/TrEMBL

A0A4X1VL86, A0A8D1SZW0, F1SAM3

Related

ENSSSCP00000004030.3, ENSSSCT00000004122.4

Conserved Domains (5) summary

cd11304
Location:273 → 378

Cadherin_repeat; Cadherin tandem repeat domain

pfam01049
Location:747 → 904

Cadherin_C; Cadherin cytoplasmic region

pfam08758
Location:31 → 121

Cadherin_pro; Cadherin prodomain like

cl09101
Location:608 → 701

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

cl28881
Location:163 → 263

CA_like; Cadherin repeat-like domain