Zfp683 zinc finger protein 683 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp683provided by MGI
Official Full Name: zinc finger protein 683provided by MGI
Primary source: MGI:MGI:3650254
See related: AllianceGenome:MGI:3650254
Gene type: pseudo
RefSeq status: INFERRED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hobit; Gm13060
Summary: Enables promoter-specific chromatin binding activity. Involved in regulation of gene expression and regulation of lymphocyte differentiation. Acts upstream of or within natural killer cell differentiation. Predicted to be located in nucleus. Orthologous to human ZNF683 (zinc finger protein 683). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 66.5 cM

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (133778506..133786252)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (134051195..134058941)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hobit and Blimp-1 regulate TRM abundance after LCMV infection by suppressing tissue exit pathways of TRM precursors.
Title: Hobit and Blimp-1 regulate T(RM) abundance after LCMV infection by suppressing tissue exit pathways of T(RM) precursors.
Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues.
Title: Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues.
We conclude that Blimp-1 rather than Hobit mediates the formation of CD8(+) tissue-resident memory cells in the lungs
Title: Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8(+) T Cells in the Lungs.
Derepression of Etv5 increases Hobit expression in Cic -deficient CD8+ T cells and consequently enhances CD8+ T memory cell formation in liver, thereby leading to liver injury.
Title: The Capicua/ETS Translocation Variant 5 Axis Regulates Liver-Resident Memory CD8(+) T-Cell Development and the Pathogenesis of Liver Injury.
Data show that zinc finger protein 683 (Hobit)-B lymphocyte-induced maturation protein 1 (Blimp-1) deficiency leads to impaired leukocyte recruitment with decreased expression of pro-inflammatory cytokines.
Title: Hobit- and Blimp-1-driven CD4(+) tissue-resident memory T cells control chronic intestinal inflammation.
These findings suggest that Blimp-1 initiates cytotoxic effector function and that Hobit maintains cytotoxicity in a deployment-ready modus in tissue-resident memory CD8 T cells.
Title: Blimp-1 induces and Hobit maintains the cytotoxic mediator granzyme B in CD8 T cells.
these results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations.
Title: Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes.
we identified Hobit (Znf683) as a previously unrecognized homolog of Blimp-1 that was specifically expressed in mouse natural killer T cells
Title: Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (4)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within NK T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionomycin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in regulation of NK T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of extrathymic T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of natural killer cell differentiation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.