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APC APC regulator of WNT signaling pathway [ Ailuropoda melanoleuca (giant panda) ]

Gene ID: 100472257, updated on 8-Mar-2024

Summary

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Gene symbol
APC
Gene description
APC regulator of WNT signaling pathway
Locus tag
PANDA_007820
See related
Ensembl:ENSAMEG00000012636
Gene type
protein coding
RefSeq status
MODEL
Organism
Ailuropoda melanoleuca
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
18
Annotation release Status Assembly Chr Location
103 current ASM200744v2 (GCF_002007445.1) 3 NC_048220.1 (82208165..82330043)
102 previous assembly AilMel_1.0 (GCF_000004335.2) Unplaced Scaffold NW_003217606.1 (263770..393061, complement)

Chromosome 3 - NC_048220.1Genomic Context describing neighboring genes Neighboring gene erythrocyte membrane protein band 4.1 like 4A Neighboring gene uncharacterized LOC117801546 Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The sequence and de novo assembly of the giant panda genome. Li R, et al. Nature, 2010 Jan 21. PMID 20010809, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables gamma-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell fate specification IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in pattern specification process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of beta-catenin destruction complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of catenin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic microtubule IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
adenomatous polyposis coli protein
Names
APC, WNT signaling pathway regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Ailuropoda melanoleuca Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM200744v2 Primary Assembly

Genomic

  1. NC_048220.1 Reference ASM200744v2 Primary Assembly

    Range
    82208165..82330043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_019799602.2 → XP_019655161.1  adenomatous polyposis coli protein isoform X1

    UniProtKB/TrEMBL
    A0A7N5P5W0, A0A7N5P9P5
    Related
    ENSAMEP00000035458.1, ENSAMET00000035323.1

  2. XM_019799606.2 → XP_019655165.1  adenomatous polyposis coli protein isoform X4

    UniProtKB/TrEMBL
    A0A7N5P9K5

  3. XM_019799608.2 → XP_019655167.1  adenomatous polyposis coli protein isoform X7

    UniProtKB/TrEMBL
    A0A7N5P9P5

  4. XM_034656614.1 → XP_034512505.1  adenomatous polyposis coli protein isoform X8

    UniProtKB/TrEMBL
    A0A7N5P9K5

  5. XM_019799607.2 → XP_019655166.1  adenomatous polyposis coli protein isoform X6

    UniProtKB/TrEMBL
    A0A7N5P9P5

  6. XM_011224905.3 → XP_011223207.1  adenomatous polyposis coli protein isoform X5

    See identical proteins and their annotated locations for XP_011223207.1

    UniProtKB/TrEMBL
    A0A7N5P9K5, D2HBD2
    Related
    ENSAMEP00000029631.1, ENSAMET00000035000.1
    Conserved Domains (14) summary
    cd00020
    Location:611 → 731
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:1637 → 1661
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:2035 → 2054
    SAMP; SAMP Motif
    pfam05937
    Location:2671 → 2844
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2224 → 2569
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:732 → 1019
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1036 → 1135
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1283 → 1368
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1662 → 1718
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1739 → 1839
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1876 → 1947
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    sd00043
    Location:465 → 508
    ARM; armadillo repeat [structural motif]

  7. XM_019799609.2 → XP_019655168.1  adenomatous polyposis coli protein isoform X9

    UniProtKB/TrEMBL
    A0A7N5P9K5

  8. XM_019799604.2 → XP_019655163.1  adenomatous polyposis coli protein isoform X3

    UniProtKB/TrEMBL
    A0A7N5KE23, A0A7N5P9P5
    Related
    ENSAMEP00000036697.1, ENSAMET00000036203.1

  9. XM_019799603.2 → XP_019655162.1  adenomatous polyposis coli protein isoform X2

    UniProtKB/TrEMBL
    A0A7N5P9P5, G1M1X1
    Related
    ENSAMEP00000013332.2, ENSAMET00000013890.2

  10. XM_019799605.2 → XP_019655164.1  adenomatous polyposis coli protein isoform X3

    UniProtKB/TrEMBL
    A0A7N5KE23, A0A7N5P9P5
Nucleotide Protein
Heading Accession and Version

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