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ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 [ Pongo abelii (Sumatran orangutan) ]

Gene ID: 100441162, updated on 3-Apr-2024

Summary

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Gene symbol
ADAMTS5
Gene description
ADAM metallopeptidase with thrombospondin type 1 motif 5
Locus tag
CR201_G0027193
See related
Ensembl:ENSPPYG00000011311
Gene type
protein coding
RefSeq status
MODEL
Organism
Pongo abelii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 22 NC_072007.2 (37067068..37118027, complement)
RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 21 NC_072006.1 (31269821..31320642, complement)

Chromosome 22 - NC_072007.2Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 1 Neighboring gene uncharacterized LOC129052440 Neighboring gene glutathione peroxidase 1-like Neighboring gene eukaryotic initiation factor 4A-I-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

  1. NC_072007.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Range
    37067068..37118027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002830585.5 → XP_002830631.1  A disintegrin and metalloproteinase with thrombospondin motifs 5

    See identical proteins and their annotated locations for XP_002830631.1

    UniProtKB/TrEMBL
    A0A2J8UKK7, A0A663DB08, H2P2U4
    Conserved Domains (4) summary
    smart00209
    Location:570 → 622
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:269 → 473
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:67 → 168
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:732 → 852
    ADAM_spacer1; ADAM-TS Spacer 1

  2. XM_009233854.4 → XP_009232129.1  A disintegrin and metalloproteinase with thrombospondin motifs 5

    See identical proteins and their annotated locations for XP_009232129.1

    UniProtKB/TrEMBL
    A0A2J8UKK7, A0A663DB08, H2P2U4
    Conserved Domains (4) summary
    smart00209
    Location:570 → 622
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:269 → 473
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:67 → 168
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:732 → 852
    ADAM_spacer1; ADAM-TS Spacer 1

  3. XM_063720867.1 → XP_063576937.1  A disintegrin and metalloproteinase with thrombospondin motifs 5

    UniProtKB/TrEMBL
    A0A2J8UKK7, A0A663DB08, H2P2U4
Nucleotide Protein
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