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ABCB4 ATP binding cassette subfamily B member 4 [ Bos taurus (cattle) ]

Gene ID: 100336913, updated on 16-Jan-2024

Summary

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Official Symbol
ABCB4provided by VGNC
Official Full Name
ATP binding cassette subfamily B member 4provided by VGNC
Primary source
VGNC:VGNC:53628
See related
Ensembl:ENSBTAG00000005653
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PGY3
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Genomic context

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Location:
chromosome: 4
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (33007201..33080045)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene phosphatidylcholine translocator ABCB4 Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene ATP-dependent translocase ABCB1 Neighboring gene carnitine O-octanoyltransferase Neighboring gene nucleophosmin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mapping the bovine homolog of the human cystic fibrosis gene. Wallis D, et al. J Hered, 1994 Nov-Dec. PMID 7527809
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
multidrug resistance protein 3; phosphatidylcholine translocator ABCB4
Names
ATP-binding cassette, sub-family B (MDR/TAP), member 4
P glycoprotein 3/ multiple drug resistance 3
XP_005205361.1
XP_010802432.1
XP_010802433.1
XP_059741815.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    33007201..33080045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010804130.3 → XP_010802432.1  phosphatidylcholine translocator ABCB4 isoform X1

    See identical proteins and their annotated locations for XP_010802432.1

    UniProtKB/TrEMBL
    E1BLT5
    Conserved Domains (3) summary
    cd03249
    Location:395 → 631
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:55 → 1263
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:61 → 345
    ABC_membrane; ABC transporter transmembrane region

  2. XM_059885832.1 → XP_059741815.1  phosphatidylcholine translocator ABCB4 isoform X2

  3. XM_010804131.4 → XP_010802433.1  phosphatidylcholine translocator ABCB4 isoform X1

    See identical proteins and their annotated locations for XP_010802433.1

    UniProtKB/TrEMBL
    E1BLT5
    Related
    ENSBTAP00000007432.6, ENSBTAT00000007432.7
    Conserved Domains (3) summary
    cd03249
    Location:395 → 631
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:55 → 1263
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:61 → 345
    ABC_membrane; ABC transporter transmembrane region

  4. XM_005205304.5 → XP_005205361.1  phosphatidylcholine translocator ABCB4 isoform X3

    See identical proteins and their annotated locations for XP_005205361.1

    Conserved Domains (5) summary
    cd03249
    Location:175 → 411
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    COG1122
    Location:174 → 401
    EcfA2; Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and metabolism, General function prediction only]
    COG1132
    Location:475 → 1052
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    pfam00664
    Location:492 → 762
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:1 → 125
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein Strain
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