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adamtsl4 ADAMTS-like 4 [ Danio rerio (zebrafish) ]

Gene ID: 100333903, updated on 25-Apr-2024

Summary

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Official Symbol
adamtsl4provided by ZNC
Official Full Name
ADAMTS-like 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-070815-2
See related
Ensembl:ENSDARG00000063407 AllianceGenome:ZFIN:ZDB-GENE-070815-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Human ortholog(s) of this gene implicated in autosomal recessive isolated ectopia lentis 2 and ectopia lentis with ectopia of pupil. Orthologous to human ADAMTSL4 (ADAMTS like 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See adamtsl4 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (1255166..1322302)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (1227237..1295021)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene regulation of nuclear pre-mRNA domain containing 2b Neighboring gene threonyl-tRNA synthetase 2, mitochondrial Neighboring gene uncharacterized LOC103908888 Neighboring gene cugbp, Elav-like family member 3b Neighboring gene uncharacterized LOC101882672

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. Huxley-Jones J, et al. BMC Evol Biol, 2007 Apr 17. PMID 17439641, Free PMC Article
  2. Regulation of cytochrome P450 expression in a novel liver cell line from zebrafish (Brachydanio rerio). Miranda CL, et al. Arch Biochem Biophys, 1993 Sep. PMID 8373170
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ADAMTS-like protein 4; thrombospondin type-1 domain-containing protein 4-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    1255166..1322302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466793.1 → XP_021322468.1  ADAMTS-like protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8M9P832
    Conserved Domains (2) summary
    smart00209
    Location:991 → 1043
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:481 → 601
    ADAM_spacer1; ADAM-TS Spacer 1

  2. XM_021466792.1 → XP_021322467.1  thrombospondin type-1 domain-containing protein 4-like isoform X1

    UniProtKB/TrEMBL
    A0A8M9NZG4
    Related
    ENSDARP00000087059.6, ENSDART00000092627.6
    Conserved Domains (3) summary
    smart00209
    Location:991 → 1043
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:481 → 601
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:1050 → 1080
    PLAC; PLAC (protease and lacunin) domain
Nucleotide Protein Strain
Heading Accession and Version

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