Il4i1b interleukin 4 induced 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il4i1bprovided by MGI
Official Full Name: interleukin 4 induced 1Bprovided by MGI
Primary source: MGI:MGI:5439399
See related: Ensembl:ENSMUSG00000074141 AllianceGenome:MGI:5439399
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LAO; Fig1; LAAO; Il4i1; mFIG1; Gm21948; Nup62-il4i1
Summary: This locus represents naturally-occurring readthrough transcription between Nup62 (nucleoporin 62) and Il4i1 (interleukin 4 induced 1). It encodes a protein sharing similarity with the protein encoded by Il4i1, but with a longer and distinct N-terminus. [provided by RefSeq, Aug 2015]
Expression: Biased expression in spleen adult (RPKM 63.6), testis adult (RPKM 40.1) and 14 other tissues See more
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Genomic context

Location:: 7 B3; 7

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (44465794..44490228)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (44816370..44840804)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data showed proteome changes in alveolar epithelial cells type II exposed to an infection with A. fumigatus with IL4I1 showing the most prominent increase in abundance both, in terms of relative abundance as well as activity. Also, in the infected lungs, there was levels of IL4I1 metabolic products.
Title: Quantitative Analysis of Proteome Modulations in Alveolar Epithelial Type II Cells in Response to Pulmonary Aspergillus fumigatus Infection.

Submit: New GeneRIF Correction

General gene information

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Markers

Fig1 (e-PCR), detects polymorphism
- UniSTS:143108

U70429 (e-PCR)
- UniSTS:179563

AI426861 (e-PCR)
- UniSTS:179565

AU015239 (e-PCR)
- UniSTS:167534

AI790512 (e-PCR)
- UniSTS:179566

NoName (e-PCR)
- UniSTS:235658

AU045898 (e-PCR)
- UniSTS:159634

RH124961 (e-PCR)
- UniSTS:161783

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-amino-acid oxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-phenylalanine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell mediated immune response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in tryptophan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in tryptophan catabolic process to indole-3-acetate	ISO Inferred from Sequence Orthology more info
involved_in tyrosine catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: L-amino-acid oxidase

Names: IL4-induced protein 1; Interleukin-4-induced protein 1; Protein Fig-1

NP_001164495.1

EC 1.4.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.