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plat plasminogen activator, tissue [ Danio rerio (zebrafish) ]

Gene ID: 100320028, updated on 25-Apr-2024

Summary

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Official Symbol
platprovided by ZNC
Official Full Name
plasminogen activator, tissueprovided by ZNC
Primary source
ZFIN:ZDB-GENE-081104-181
See related
Ensembl:ENSDARG00000062707 AllianceGenome:ZFIN:ZDB-GENE-081104-181
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-220d9.5; si:dkeyp-117b11.4
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in plasminogen activation and smooth muscle cell migration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in ovarian follicle. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia (multiple). Orthologous to human PLAT (plasminogen activator, tissue type). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (2260244..2306597, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (2201799..2248055, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene integumentary mucin C.1-like Neighboring gene uncharacterized LOC100536595 Neighboring gene inhibitor of nuclear factor kappa B kinase subunit beta Neighboring gene voltage-dependent anion channel 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Increased anxiety was found in serpini1 knockout zebrafish larval. Han S, et al. Biochem Biophys Res Commun, 2021 Jan 1. PMID 33168193
  2. Igf3 serves as a mediator of luteinizing hormone in zebrafish ovulation. Li J, et al. Biol Reprod, 2018 Dec 1. PMID 29945206
  3. Targeted gene disruption in zebrafish reveals noncanonical functions of LH signaling in reproduction. Chu L, et al. Mol Endocrinol, 2014 Nov. PMID 25238195, Free PMC Article
  4. Selecting biologically informative genes in co-expression networks with a centrality score. Azuaje FJ. Biol Direct, 2014 Jun 19. PMID 24947308, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within digestion IEA
Inferred from Electronic Annotation
more info
  
involved_in plasminogen activation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within plasminogen activation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in smooth muscle cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tissue-type plasminogen activator
XP_002663097.1
XP_021334027.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    2260244..2306597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478352.1 → XP_021334027.1  tissue-type plasminogen activator isoform X2

    UniProtKB/TrEMBL
    A0A8M9PR58
    Conserved Domains (4) summary
    smart00130
    Location:210 → 293
    KR; Kringle domain
    cd00054
    Location:86 → 115
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00108
    Location:120 → 203
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:333 → 573
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_002663051.5 → XP_002663097.1  tissue-type plasminogen activator isoform X1

    UniProtKB/TrEMBL
    A0A8M1RLZ3, F1QB78
    Related
    ENSDARP00000120778.1, ENSDART00000147275.2
    Conserved Domains (5) summary
    smart00020
    Location:331 → 571
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:211 → 294
    KR; Kringle domain
    cd00054
    Location:87 → 116
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00108
    Location:121 → 204
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:334 → 574
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein Strain
Heading Accession and Version

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