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APH1A aph-1 homolog A, gamma-secretase subunit [ Sus scrofa (pig) ]

Gene ID: 100154978, updated on 8-Mar-2024

Summary

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Official Symbol
APH1Aprovided by VGNC
Official Full Name
aph-1 homolog A, gamma-secretase subunitprovided by VGNC
Primary source
VGNC:VGNC:85409
See related
Ensembl:ENSSSCG00000028297
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in lung (RPKM 53.9), kidney (RPKM 48.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 4 NC_010446.5 (98817574..98821255)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003538109.2 (12830..16760, complement)

Chromosome 4 - NC_010446.5Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S21 Neighboring gene circadian associated repressor of transcription Neighboring gene chromosome 4 C1orf54 homolog Neighboring gene carbonic anhydrase 14 Neighboring gene acidic nuclear phosphoprotein 32 family member E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Comparative analysis of protein coding sequences from human, mouse and the domesticated pig. Jørgensen FG, et al. BMC Biol, 2005 Jan 28. PMID 15679890, Free PMC Article
  2. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of gamma-secretase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
gamma-secretase subunit APH-1A
Names
anterior pharynx defective 1 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244487.1 → NP_001231416.1  gamma-secretase subunit APH-1A

    Status: PROVISIONAL

    Source sequence(s)
    AY609845, BW976365, DN121186
    UniProtKB/TrEMBL
    A0A480ZS76, A0A4X1SIA7, I3L8R2
    Related
    ENSSSCP00000020423.2, ENSSSCT00000023376.4
    Conserved Domains (1) summary
    pfam06105
    Location:3 → 233
    Aph-1; Aph-1 protein

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010446.5 Reference Sscrofa11.1 Primary Assembly

    Range
    98817574..98821255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021088563.1 → XP_020944222.1  gamma-secretase subunit APH-1A isoform X1

    UniProtKB/TrEMBL
    A0A287B0C6, A0A4X1SH86, A0A4X1SH94, A0A8D0IT63
    Conserved Domains (1) summary
    pfam06105
    Location:3 → 233
    Aph-1; Aph-1 protein
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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