cep70 centrosomal protein 70 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cep70provided by ZNC
Official Full Name: centrosomal protein 70provided by ZNC
Primary source: ZFIN:ZDB-GENE-070705-311
See related: Ensembl:ENSDARG00000076965 AllianceGenome:ZFIN:ZDB-GENE-070705-311
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-170g11.4
Summary: Predicted to enable gamma-tubulin binding activity. Acts upstream of or within cilium assembly and epithelial cilium movement involved in determination of left/right asymmetry. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in centrosome. Is expressed in central canal; hair cell; otic vesicle; pronephric duct; and solid lens vesicle. Orthologous to human CEP70 (centrosomal protein 70). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (12604302..12626244, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (12579501..12601279, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cep70 and Cep131 contribute to ciliogenesis in many tissues in the zebrafish embryo.
Title: Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables gamma-tubulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: centrosomal protein of 70 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114576.1 → NP_001108048.1 centrosomal protein of 70 kDa

See identical proteins and their annotated locations for NP_001108048.1

Status: PROVISIONAL

Source sequence(s)

BC154450

UniProtKB/TrEMBL

A8WFT5

Related

ENSDARP00000104406.3, ENSDART00000115344.5

Conserved Domains (2) summary

PTZ00400
Location:183 → 325

PTZ00400; DnaK-type molecular chaperone; Provisional

pfam15066
Location:53 → 167

CAGE1; Cancer-associated gene protein 1 family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

12604302..12626244 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021469288.1 → XP_021324963.1 centrosomal protein of 70 kDa isoform X3

UniProtKB/TrEMBL

A0A8M9PDS2

Conserved Domains (2) summary

cl25732
Location:51 → 408

SMC_N; RecF/RecN/SMC N terminal domain

cl26953
Location:183 → 325

HSP70; Hsp70 protein
XM_021469287.1 → XP_021324962.1 centrosomal protein of 70 kDa isoform X1

UniProtKB/TrEMBL

A0A8M9P470

Conserved Domains (2) summary

cl25732
Location:71 → 428

SMC_N; RecF/RecN/SMC N terminal domain

cl26953
Location:203 → 345

HSP70; Hsp70 protein
XM_017353091.2 → XP_017208580.1 centrosomal protein of 70 kDa isoform X2

UniProtKB/TrEMBL

A0A8M6Z3B7