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AKT1 AKT serine/threonine kinase 1 [ Sus scrofa (pig) ]

Gene ID: 100126861, updated on 8-Mar-2024

Summary

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Official Symbol
AKT1provided by VGNC
Official Full Name
AKT serine/threonine kinase 1provided by VGNC
Primary source
VGNC:VGNC:96930
See related
Ensembl:ENSSSCG00000039139
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
Akt; PKB
Expression
Ubiquitous expression in subcutaneous adipose (RPKM 118.2), lung (RPKM 70.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
16
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) Unplaced Scaffold NW_018084979.1 (3040277..3061464, complement)

NW_018084979.1Genomic Context describing neighboring genes Neighboring gene adenylosuccinate synthase 1 Neighboring gene SIVA1 apoptosis inducing factor Neighboring gene collagen alpha-1(I) chain-like Neighboring gene zinc finger and BTB domain containing 42 Neighboring gene uncharacterized LOC110258334

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_018084979 Unplaced Scaffold Reference Sscrofa11.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Metabolic Transition of Milk Lactose Synthesis and Up-regulation by AKT1 in Sows from Late Pregnancy to Lactation. Chen F, et al. Cell Biochem Biophys, 2017 Mar. PMID 28025803
  2. Role of phosphatidylinositol 3-kinase (PI3K) and Akt1 kinase in porcine reproductive and respiratory syndrome virus (PRRSV) replication. Wang X, et al. Arch Virol, 2014 Aug. PMID 24532302
  3. AKT (protein kinase B) is implicated in meiotic maturation of porcine oocytes. Kalous J, et al. Reproduction, 2009 Oct. PMID 19633130
  4. Dynamic and static mechanical compression affects Akt phosphorylation in porcine patellofemoral joint cartilage. Niehoff A, et al. J Orthop Res, 2008 May. PMID 18050339
  5. Akt is a critical node of acute myocardial insulin resistance and cardiac dysfunction after cardiopulmonary bypass. Wang Z, et al. Life Sci, 2019 Oct 1. PMID 31394126

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Preterm birth alters the feeding-induced activation of Akt signaling in the muscle of neonatal piglets.
    Title: Preterm birth alters the feeding-induced activation of Akt signaling in the muscle of neonatal piglets.
  2. These data showed that cardiopulmonary bypass elicited not only hyperglycemia and hyperinsulinemia, but also inactivated Akt, and impaired the transposition of membrane glucose transporter-4 (GLUT-4), reduced glucose uptake and ATP production in the myocardium as well, which in turn was accompanied with cardiac dysfunction.
    Title: Akt is a critical node of acute myocardial insulin resistance and cardiac dysfunction after cardiopulmonary bypass.
  3. Once inside in proximal tubule cells, glucose is diverted to the hexosamine biosynthetic pathway increasing O-GlcNAcylation of several intracellular proteins, including PKB.
    Title: High glucose reduces megalin-mediated albumin endocytosis in renal proximal tubule cells through protein kinase B O-GlcNAcylation.
  4. Studied the effects of microRNA-27a on myogenin expression and the Akt/FoxO1 signal pathway during porcine myoblast differentiation. Overexpression of miR-27a suppressed myogenin expression during porcine myoblast differentiation, whereas inhibition of miR-27a promoted the mRNA and protein expression levels of myogenin; overexpression of miR-27a decreased the level of P-Akt/Akt and increased the protein level of FoxO1.
    Title: Effects of MicroRNA-27a on Myogenin Expression and Akt/FoxO1 Signal Pathway during Porcine Myoblast Differentiation.
  5. SCF is a critical regulatory factor for conceptus development and implantation during pregnancy in pigs.
    Title: Stem cell factor-induced AKT cell signaling pathway: Effects on porcine trophectoderm and uterine luminal epithelial cells.
  6. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.
    Title: Glycine enhances muscle protein mass associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing TLR4 and NOD2 signaling in piglets challenged with LPS.
  7. Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt signaling pathway may be involved.
    Title: Homocysteine ameliorates the endothelium-independent hypoxic vasoconstriction via the suppression of phosphatidylinositol 3-kinase/Akt pathway in porcine coronary arteries.
  8. In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 could positively regulate lactose synthesis.
    Title: Metabolic Transition of Milk Lactose Synthesis and Up-regulation by AKT1 in Sows from Late Pregnancy to Lactation.
  9. In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.
    Title: The involvement of FAK-PI3K-AKT-Rac1 pathway in porcine reproductive and respiratory syndrome virus entry.
  10. Host PI3K and Akt1 play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.
    Title: Role of phosphatidylinositol 3-kinase (PI3K) and Akt1 kinase in porcine reproductive and respiratory syndrome virus (PRRSV) replication.
Submit: New GeneRIF Correction See all GeneRIFs (17)

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
RAC-alpha serine/threonine-protein kinase
Names
protein kinase B
v-akt murine thymoma viral oncogene homolog 1
v-akt murine thymoma viral oncogene-like 1
NP_001153248.1
XP_020937158.1
XP_020937159.1
XP_020937160.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159776.1 → NP_001153248.1  RAC-alpha serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_001153248.1

    Status: PROVISIONAL

    Source sequence(s)
    AB499527
    UniProtKB/TrEMBL
    A0A8D0XMG2, C1PIG3
    Conserved Domains (2) summary
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124 → 479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NW_018084979.1 Reference Sscrofa11.1 Primary Assembly

    Range
    3040277..3061464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021081500.1 → XP_020937159.1  RAC-alpha serine/threonine-protein kinase isoform X2

    UniProtKB/TrEMBL
    A0A287AR39, A0A4X1TYM4, A0A8D0XMG2, G9BWQ1
    Related
    ENSSSCP00000046325.3, ENSSSCT00000050545.3
    Conserved Domains (2) summary
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124 → 479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)

  2. XM_021081501.1 → XP_020937160.1  RAC-alpha serine/threonine-protein kinase isoform X2

    UniProtKB/TrEMBL
    A0A287AR39, A0A4X1TYM4, A0A8D0XMG2, G9BWQ1
    Conserved Domains (2) summary
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:124 → 479
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)

  3. XM_021081499.1 → XP_020937158.1  RAC-alpha serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8D0XMG2
    Conserved Domains (2) summary
    cd01241
    Location:87 → 181
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05594
    Location:194 → 549
    STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
Nucleotide Protein
Heading Accession and Version

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