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Tdrd7 tudor domain containing 7 [ Mus musculus (house mouse) ]

Gene ID: 100121, updated on 21-Apr-2024

Summary

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Official Symbol
Tdrd7provided by MGI
Official Full Name
tudor domain containing 7provided by MGI
Primary source
MGI:MGI:2140279
See related
Ensembl:ENSMUSG00000035517 AllianceGenome:MGI:2140279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PCTAIRE2BP; 5730495N10Rik
Summary
Predicted to enable mRNA binding activity and protein N-terminus binding activity. Involved in lens fiber cell differentiation; lens morphogenesis in camera-type eye; and spermatogenesis. Acts upstream of or within germ cell development. Located in P granule and chromatoid body. Part of ribonucleoprotein complex. Is expressed in several structures, including central nervous system; olfactory epithelium; retina; and seminiferous tubule. Human ortholog(s) of this gene implicated in cataract 36. Orthologous to human TDRD7 (tudor domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 28.4), placenta adult (RPKM 9.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B1; 4 24.48 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45965335..46034766)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45965027..46034766)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor binding protein-like 1 Neighboring gene STARR-seq mESC enhancer starr_10113 Neighboring gene STARR-seq mESC enhancer starr_10114 Neighboring gene STRA6-like Neighboring gene coiled-coil domain containing 180 Neighboring gene tropomodulin 1 Neighboring gene predicted gene, 52729 Neighboring gene STARR-seq mESC enhancer starr_10118 Neighboring gene predicted gene, 54220

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interferon-stimulated gene TDRD7 interacts with AMPK and inhibits its activation to suppress viral replication and pathogenesis.
    Title: Interferon-stimulated gene TDRD7 interacts with AMPK and inhibits its activation to suppress viral replication and pathogenesis.
  2. The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology.
    Title: The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology.
  3. The interferon-inducible protein TDRD7 inhibits AMP-activated protein kinase and thereby restricts autophagy-independent virus replication.
    Title: The interferon-inducible protein TDRD7 inhibits AMP-activated protein kinase and thereby restricts autophagy-independent virus replication.
  4. results identify TRPC3 as a pivotal signaling gateway in Ca(2+)-dependent control of cardiac gene expression
    Title: Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.
  5. Tdrd7 nullizygosity causes cataract and glaucoma and arrest in spermatogenesis;TDRD7 coimmunoprecipitates with specific lens mRNAs; required for posttranscriptional control of mRNAs critical to normal lens development and RNA granule function
    Title: Mutations in the RNA granule component TDRD7 cause cataract and glaucoma.
  6. Tudor-related proteins, which contain multiple repeats of the Tudor domain, constitute an evolutionarily conserved class of nuage components in the germ-line, and their localization or accumulation to nuage is likely conferred by a Tudor domain structure
    Title: Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC36668

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in P granule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within germ cell development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lens fiber cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lens fiber cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lens fiber cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in lens morphogenesis in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lens morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lens morphogenesis in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in piRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatoid body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tudor domain-containing protein 7
Names
PCTAIRE2-binding protein
trap
tudor repeat associator with PCTAIRE 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290475.1 → NP_001277404.1  tudor domain-containing protein 7 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK077641, AK150077, BB619178, BC029689, BY427120, CX563409, CX563831, CX568265
    Consensus CDS
    CCDS71381.1
    UniProtKB/TrEMBL
    A0A0A0MQD1
    Related
    ENSMUSP00000103406.3, ENSMUST00000107777.9
    Conserved Domains (5) summary
    cd04508
    Location:728 → 773
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd09973
    Location:256 → 322
    LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09974
    Location:361 → 425
    LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09986
    Location:38 → 124
    LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
    pfam00567
    Location:932 → 1047
    TUDOR; Tudor domain

  2. NM_001355189.1 → NP_001342118.1  tudor domain-containing protein 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AK161319, BE950089, BY427120, CF736406, CN539534, CX566254
    Consensus CDS
    CCDS18142.1
    UniProtKB/Swiss-Prot
    B1AWG7, B1AWH5, Q8K1H1, Q8R181
    Conserved Domains (4) summary
    cd09973
    Location:223 → 289
    LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09974
    Location:328 → 392
    LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09986
    Location:5 → 91
    LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
    pfam00567
    Location:903 → 1013
    TUDOR; Tudor domain

  3. NM_146142.2 → NP_666254.1  tudor domain-containing protein 7 isoform 2

    See identical proteins and their annotated locations for NP_666254.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    BC029689, BY427120, BY783424
    Consensus CDS
    CCDS18142.1
    UniProtKB/Swiss-Prot
    B1AWG7, B1AWH5, Q8K1H1, Q8R181
    Related
    ENSMUSP00000099993.2, ENSMUST00000102929.2
    Conserved Domains (4) summary
    cd09973
    Location:223 → 289
    LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09974
    Location:328 → 392
    LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09986
    Location:5 → 91
    LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
    pfam00567
    Location:903 → 1013
    TUDOR; Tudor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    45965335..46034766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537518.2 → XP_006537581.1  tudor domain-containing protein 7 isoform X2

    Conserved Domains (4) summary
    cd09973
    Location:256 → 322
    LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09974
    Location:361 → 425
    LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09986
    Location:38 → 124
    LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
    pfam00567
    Location:676 → 795
    TUDOR; Tudor domain

  2. XM_030253050.2 → XP_030108910.1  tudor domain-containing protein 7 isoform X3

    Conserved Domains (4) summary
    cd09973
    Location:223 → 289
    LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09974
    Location:328 → 392
    LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09986
    Location:5 → 91
    LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
    pfam00567
    Location:643 → 762
    TUDOR; Tudor domain

  3. XM_030253051.2 → XP_030108911.1  tudor domain-containing protein 7 isoform X4

    Conserved Domains (2) summary
    cd09974
    Location:55 → 119
    LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
    pfam00567
    Location:630 → 740
    TUDOR; Tudor domain

  4. XM_030253049.2 → XP_030108909.1  tudor domain-containing protein 7 isoform X1

    UniProtKB/Swiss-Prot
    B1AWG7, B1AWH5, Q8K1H1, Q8R181
    Conserved Domains (4) summary
    cd09973
    Location:223 → 289
    LOTUS_2_TDRD7; The second LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09974
    Location:328 → 392
    LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
    cd09986
    Location:5 → 91
    LOTUS_1_TDRD7; The first LOTUS domain on Tudor-containing protein 7 (TDRD7)
    pfam00567
    Location:903 → 1013
    TUDOR; Tudor domain

  5. XM_006537519.2 → XP_006537582.1  tudor domain-containing protein 7 isoform X5

    Conserved Domains (2) summary
    cd09974
    Location:3 → 67
    LOTUS_3_TDRD7; The third LOTUS domain on Tudor-containing protein 7 (TDRD7)
    pfam00567
    Location:578 → 688
    TUDOR; Tudor domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1H1.1 GenPept UniProtKB/Swiss-Prot:Q8K1H1

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