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A2ML1 alpha-2-macroglobulin like 1 [ Equus caballus (horse) ]

Gene ID: 100061421, updated on 8-Mar-2024

Summary

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Official Symbol
A2ML1provided by VGNC
Official Full Name
alpha-2-macroglobulin like 1provided by VGNC
Primary source
VGNC:VGNC:14882
See related
Ensembl:ENSECAG00000024232
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human all
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Genomic context

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Location:
chromosome: 6
Exon count:
37
Annotation release Status Assembly Chr Location
103 current EquCab3.0 (GCF_002863925.1) 6 NC_009149.3 (36959094..37019643)
102 previous assembly EquCab2.0 (GCF_000002305.2) 6 NC_009149.2 (35889251..35964935)

Chromosome 6 - NC_009149.3Genomic Context describing neighboring genes Neighboring gene microfibril associated protein 5 Neighboring gene ribosomal modification protein rimK like family member B Neighboring gene polyhomeotic homolog 1 Neighboring gene mannose-6-phosphate receptor, cation dependent

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
alpha-2-macroglobulin-like protein 1
Names
alpha-2-macroglobulin-like protein 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009149.3 Reference EquCab3.0 Primary Assembly

    Range
    36959094..37019643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023643099.1 → XP_023498867.1  alpha-2-macroglobulin-like protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A9L0TIG8
    Conserved Domains (6) summary
    cd02897
    Location:888 → 1183
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:668 → 755
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:52 → 141
    A2M_N; MG2 domain
    pfam07677
    Location:1294 → 1381
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:385 → 528
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl27039
    Location:720 → 813
    A2M; Alpha-2-macroglobulin family

  2. XM_014740588.2 → XP_014596074.2  alpha-2-macroglobulin-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A9L0TIG8, F6YA47
    Related
    ENSECAP00000021799.2, ENSECAT00000026158.3
    Conserved Domains (6) summary
    cd02897
    Location:959 → 1254
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:739 → 826
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:123 → 212
    A2M_N; MG2 domain
    pfam07677
    Location:1365 → 1452
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:456 → 599
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl27039
    Location:791 → 884
    A2M; Alpha-2-macroglobulin family

  3. XM_014740589.2 → XP_014596075.2  alpha-2-macroglobulin-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A9L0TIG8
    Conserved Domains (6) summary
    cd02897
    Location:959 → 1254
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:739 → 826
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:123 → 212
    A2M_N; MG2 domain
    pfam07677
    Location:1365 → 1452
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:456 → 599
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl27039
    Location:791 → 884
    A2M; Alpha-2-macroglobulin family
Nucleotide Protein
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