ARHGAP24 Rho GTPase activating protein 24 [Equus caballus (horse)] - Gene

Summary

Official Symbol: ARHGAP24provided by VGNC
Official Full Name: Rho GTPase activating protein 24provided by VGNC
Primary source: VGNC:VGNC:15464
See related: Ensembl:ENSECAG00000033662
Gene type: protein coding
RefSeq status: MODEL
Organism: Equus caballus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
103	current	EquCab3.0 (GCF_002863925.1)	3	NC_009146.3 (53037500..53502540, complement)
102	previous assembly	EquCab2.0 (GCF_000002305.2)	3	NC_009146.2 (51563957..52028558, complement)

Chromosome 3 - NC_009146.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of Rac protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of ruffle assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in wound healing, spreading of epidermal cells	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in focal adhesion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: rho GTPase-activating protein 24

Names: rho GTPase-activating protein 24-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

NC_009146.3 Reference EquCab3.0 Primary Assembly

Range

53037500..53502540 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001495116.4 → XP_001495166.1 rho GTPase-activating protein 24 isoform X1

See identical proteins and their annotated locations for XP_001495166.1

UniProtKB/TrEMBL

A0A3Q2HH15, A0A3Q2HMG0

Related

ENSECAP00000035897.2, ENSECAT00000049205.3

Conserved Domains (4) summary

cd04390
Location:130 → 328

RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...

cd13379
Location:18 → 130

PH_RhoGap24; Rho GTPase activating protein 24 Pleckstrin homology (PH) domain

pfam00169
Location:20 → 123

PH; PH domain

pfam08614
Location:610 → 723

ATG16; Autophagy protein 16 (ATG16)
XM_001495155.4 → XP_001495205.1 rho GTPase-activating protein 24 isoform X3

See identical proteins and their annotated locations for XP_001495205.1

UniProtKB/TrEMBL

A0A3Q2L7F0

Conserved Domains (4) summary

cd04390
Location:36 → 234

RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...

pfam00169
Location:4 → 29

PH; PH domain

pfam08614
Location:516 → 629

ATG16; Autophagy protein 16 (ATG16)

cl17171
Location:1 → 36

PH-like; Pleckstrin homology-like domain
XM_003364662.4 → XP_003364710.1 rho GTPase-activating protein 24 isoform X3

See identical proteins and their annotated locations for XP_003364710.1

UniProtKB/TrEMBL

A0A3Q2L7F0

Conserved Domains (4) summary

cd04390
Location:36 → 234

RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...

pfam00169
Location:4 → 29

PH; PH domain

pfam08614
Location:516 → 629

ATG16; Autophagy protein 16 (ATG16)

cl17171
Location:1 → 36

PH-like; Pleckstrin homology-like domain
XM_001495175.5 → XP_001495225.3 rho GTPase-activating protein 24 isoform X2

See identical proteins and their annotated locations for XP_001495225.3

UniProtKB/TrEMBL

A0A3Q2I059, A0A3Q2I0X2, A0A3Q2L7F0

Related

ENSECAP00000039358.2, ENSECAT00000042465.3

Conserved Domains (3) summary

cd04390
Location:39 → 237

RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...

pfam09726
Location:379 → 647

Macoilin; Transmembrane protein

cl02571
Location:231 → 388

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.