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APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F [ Ovis aries (sheep) ]

Gene ID: 100037691, updated on 2-May-2024

Summary

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Gene symbol
APOBEC3F
Gene description
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
See related
EnsemblRapid:ENSOARG00020011837
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
APOBEC3Z2; APOBEC3Z3
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Genomic context

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Location:
chromosome: 3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 3 NC_056056.1 (216380024..216394969)

Chromosome 3 - NC_056056.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like Neighboring gene glycine cleavage system H protein, mitochondrial-like Neighboring gene chromobox 7 Neighboring gene uncharacterized LOC132659640 Neighboring gene platelet derived growth factor subunit B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056056.1 Chromosome 3 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteins. Jónsson SR, et al. Nucleic Acids Res, 2006. PMID 17038330, Free PMC Article
  2. The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals. LaRue RS, et al. BMC Mol Biol, 2008 Nov 18. PMID 19017397, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytidine deaminase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA cytosine deamination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in DNA demethylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytidine to uridine editing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA dC->dU-editing enzyme APOBEC-3F
NP_001087253.1
XP_027821509.1
XP_027821510.1
XP_042101069.1
XP_060267543.1
XP_060267545.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093784.1 → NP_001087253.1  DNA dC->dU-editing enzyme APOBEC-3F

    See identical proteins and their annotated locations for NP_001087253.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ974645
    UniProtKB/TrEMBL
    A0A6P3CWN6, A0FDH1, B7TA00
    Related
    ENSOARP00020015068.2, ENSOART00020018225.2
    Conserved Domains (3) summary
    cd01283
    Location:212 → 310
    cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
    pfam05240
    Location:128 → 173
    APOBEC_C; APOBEC-like C-terminal domain
    pfam08210
    Location:16 → 186
    APOBEC_N; APOBEC-like N-terminal domain

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056056.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    216380024..216394969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042245135.1 → XP_042101069.1  DNA dC->dU-editing enzyme APOBEC-3F isoform X5

    UniProtKB/TrEMBL
    B7T160
    Related
    ENSOARP00020015141.2, ENSOART00020018312.2
    Conserved Domains (1) summary
    pfam18772
    Location:11 → 189
    APOBEC2

  2. XM_060411560.1 → XP_060267543.1  DNA dC->dU-editing enzyme APOBEC-3F isoform X1

  3. XM_027965708.3 → XP_027821509.1  DNA dC->dU-editing enzyme APOBEC-3F isoform X2

    Related
    ENSOARP00020041164.1, ENSOART00020074413.1

  4. XM_060411562.1 → XP_060267545.1  DNA dC->dU-editing enzyme APOBEC-3F isoform X3

  5. XM_027965709.2 → XP_027821510.1  DNA dC->dU-editing enzyme APOBEC-3F isoform X4

    UniProtKB/TrEMBL
    A0A6P7DS54, B7T161, B7TA02
    Related
    ENSOARP00020015202.1, ENSOART00020018376.2
Nucleotide Protein Strain
Heading Accession and Version

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