U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ifi208 interferon activated gene 208 [ Mus musculus (house mouse) ]

Gene ID: 100033459, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Ifi208provided by MGI
Official Full Name
interferon activated gene 208provided by MGI
Primary source
MGI:MGI:2442822
See related
Ensembl:ENSMUSG00000066677 AllianceGenome:MGI:2442822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pydc3; Pyr-rv1; NG2creBAC; 9830148g24rik; E430029J22Rik; Tg(Cspg4-cre)1Akik
Summary
Predicted to enable double-stranded DNA binding activity. Predicted to be involved in cellular response to interferon-beta. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 5.2), mammary gland adult (RPKM 5.0) and 8 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1 H3; 1 80.57 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173501194..173525959)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173673628..173698393)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene interferon activated gene 213 Neighboring gene STARR-positive B cell enhancer ABC_E11699 Neighboring gene STARR-seq mESC enhancer starr_03081 Neighboring gene STARR-positive B cell enhancer ABC_E10060 Neighboring gene STARR-positive B cell enhancer ABC_E5857 Neighboring gene STARR-positive B cell enhancer ABC_E4393 Neighboring gene interferon activated gene 209 Neighboring gene STARR-positive B cell enhancer mm9_chr1:175599072-175599372 Neighboring gene STARR-seq mESC enhancer starr_03083 Neighboring gene pyrin and HIN domain family, member 1 pseudogene Neighboring gene predicted gene 7871

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. NG2 cells in white matter but not gray matter proliferate in response to PDGF. Hill RA, et al. J Neurosci, 2013 Sep 4. PMID 24005306, Free PMC Article
  2. Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Armulik A, et al. Dev Cell, 2011 Aug 16. PMID 21839917
  3. Median eminence blood flow influences food intake by regulating ghrelin access to the metabolic brain. Romanò N, et al. JCI Insight, 2023 Feb 8. PMID 36574295, Free PMC Article
  4. A dominant tubulin mutation causes cerebellar neurodegeneration in a genetic model of tubulinopathy. Fertuzinhos S, et al. Sci Adv, 2022 Feb 18. PMID 35171680, Free PMC Article
  5. Interpericyte tunnelling nanotubes regulate neurovascular coupling. Alarcon-Martinez L, et al. Nature, 2020 Sep. PMID 32788726

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
interferon-activable protein 208
Names
inteferon-activable protein 208
pyrin domain containing 3
pyrin domain-containing protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162938.2 → NP_001156410.1  interferon-activable protein 208 isoform 1

    See identical proteins and their annotated locations for NP_001156410.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC117682
    Consensus CDS
    CCDS48451.1
    UniProtKB/Swiss-Prot
    Q3V3Q4, Q8BLW5
    Related
    ENSMUSP00000083039.4, ENSMUST00000085876.12
    Conserved Domains (2) summary
    cd08305
    Location:14 → 84
    Pyrin; Pyrin: a protein-protein interaction domain
    pfam15695
    Location:505 → 570
    HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113

  2. NM_001379481.1 → NP_001366410.1  interferon-activable protein 208 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117682
    Conserved Domains (1) summary
    cd08305
    Location:14 → 84
    Pyrin; a protein-protein interaction domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    173501194..173525959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238729.3 → XP_011237031.1  interferon-activable protein 208 isoform X1

    Conserved Domains (4) summary
    PRK06347
    Location:88 → 228
    PRK06347; 1,4-beta-N-acetylmuramoylhydrolase
    cd08305
    Location:14 → 84
    Pyrin; a protein-protein interaction domain
    TIGR00601
    Location:176 → 345
    rad23; UV excision repair protein Rad23
    pfam15695
    Location:505 → 572
    HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V3Q4.1 GenPept UniProtKB/Swiss-Prot:Q3V3Q4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous