tdo2a tryptophan 2,3-dioxygenase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tdo2aprovided by ZNC
Official Full Name: tryptophan 2,3-dioxygenase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1187
See related: Ensembl:ENSDARG00000071429 AllianceGenome:ZFIN:ZDB-GENE-030131-1187
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tdo2; fb62b10; wu:fb62b10; zgc:103693
Summary: Predicted to enable heme binding activity and tryptophan 2,3-dioxygenase activity. Predicted to be involved in protein homotetramerization; tryptophan catabolic process to acetyl-CoA; and tryptophan catabolic process to kynurenine. Predicted to act upstream of or within tryptophan catabolic process. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (36738074..36750584)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (36397760..36410270)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables tryptophan 2,3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tryptophan 2,3-dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables tryptophan 2,3-dioxygenase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within tryptophan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process to acetyl-CoA	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tryptophan catabolic process to kynurenine	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process to kynurenine	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process to kynurenine	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tryptophan 2,3-dioxygenase A

NP_001096086.1

EC 1.13.11.11

XP_021336628.1

EC 1.13.11.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102616.2 → NP_001096086.1 tryptophan 2,3-dioxygenase A

See identical proteins and their annotated locations for NP_001096086.1

Status: PROVISIONAL

Source sequence(s)

BC150376

UniProtKB/Swiss-Prot

A7E2J5, A7MBU6

Related

ENSDARP00000096367.4, ENSDART00000105590.6

Conserved Domains (1) summary

pfam03301
Location:25 → 371

Trp_dioxygenase; Tryptophan 2,3-dioxygenase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

36738074..36750584

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480953.1 → XP_021336628.1 tryptophan 2,3-dioxygenase A isoform X1

UniProtKB/TrEMBL

A0A8M9QAT4

Related

ENSDART00000150731.2

Conserved Domains (1) summary

pfam03301
Location:1 → 265

Trp_dioxygenase; Tryptophan 2,3-dioxygenase