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mta3 metastasis associated 1 family, member 3 [ Danio rerio (zebrafish) ]

Gene ID: 100003254, updated on 27-Mar-2024

Summary

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Official Symbol
mta3provided by ZNC
Official Full Name
metastasis associated 1 family, member 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6485
See related
Ensembl:ENSDARG00000054903 AllianceGenome:ZFIN:ZDB-GENE-030131-6485
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mta1; fj99h01; zgc:56396; wu:fj99h01
Summary
Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Acts upstream of or within primitive hemopoiesis. Predicted to be located in nucleus. Predicted to be part of NuRD complex. Predicted to be active in nucleoplasm. Is expressed in blastodisc; central nervous system; and intermediate cell mass of mesoderm. Orthologous to human MTA3 (metastasis associated 1 family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (25223843..25285538)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (25132483..25175769)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 7A2 like Neighboring gene potassium voltage-gated channel, subfamily G, member 3 Neighboring gene transfer RNA isoleucine (anticodon UAU) Neighboring gene hydroxycarboxylic acid receptor 1-4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos. Li X, et al. Blood, 2009 Dec 24. PMID 19864643
  2. Dynamic Editome of Zebrafish under Aminoglycosides Treatment and Its Potential Involvement in Ototoxicity. Yan S, et al. Front Pharmacol, 2017. PMID 29213239, Free PMC Article
  3. Specific NuRD components are required for fin regeneration in zebrafish. Pfefferli C, et al. BMC Biol, 2014 Apr 29. PMID 24779377, Free PMC Article
  4. miR-34b regulates multiciliogenesis during organ formation in zebrafish. Wang L, et al. Development, 2013 Jul. PMID 23698347
  5. Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes. Can H, et al. BMC Genomics, 2020 Jul 8. PMID 32640983, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings suggest that Mta3-NuRD complex, inclding component HDAC1, is essential for the initiation of primitive hematopoiesis.
    Title: Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC56396, MGC77410

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within primitive hemopoiesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within primitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
metastasis-associated protein MTA3
Names
metastasis associated family, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199912.2 → NP_956206.1  metastasis-associated protein MTA3

    See identical proteins and their annotated locations for NP_956206.1

    Status: PROVISIONAL

    Source sequence(s)
    BC049310
    UniProtKB/TrEMBL
    Q7ZUE1
    Related
    ENSDARP00000071648.5, ENSDART00000077180.7
    Conserved Domains (6) summary
    smart00717
    Location:269 → 316
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:270 → 315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:374 → 425
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:378 → 414
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:3 → 171
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150 → 201
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    25223843..25285538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479998.1 → XP_021335673.1  metastasis-associated protein MTA3 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IL54, A0A8M9Q852, E7EY65
    Related
    ENSDARP00000109572.1, ENSDART00000122665.3
    Conserved Domains (4) summary
    cd11661
    Location:270 → 315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:374 → 425
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3 → 171
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150 → 201
    ELM2; ELM2 domain

  2. XM_021479999.1 → XP_021335674.1  metastasis-associated protein MTA3 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QE16
    Conserved Domains (4) summary
    cd11661
    Location:270 → 315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:374 → 425
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3 → 171
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150 → 201
    ELM2; ELM2 domain

  3. XM_021480000.1 → XP_021335675.1  metastasis-associated protein MTA3 isoform X3

    UniProtKB/TrEMBL
    A0A8M9QMB6
    Conserved Domains (4) summary
    cd11661
    Location:270 → 315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:374 → 425
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3 → 171
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150 → 201
    ELM2; ELM2 domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394845.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    96401..139687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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