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hectd1 HECT domain containing 1 [ Danio rerio (zebrafish) ]

Gene ID: 100002034, updated on 27-Mar-2024

Summary

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Official Symbol
hectd1provided by ZNC
Official Full Name
HECT domain containing 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-153
See related
Ensembl:ENSDARG00000054213 AllianceGenome:ZFIN:ZDB-GENE-030616-153
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92832; wu:fc30d02; wu:fc49f09; wu:fd99d04; zgc:123053; si:dz142b24.4
Summary
Predicted to enable metal ion binding activity and ubiquitin-protein transferase activity. Predicted to be involved in anatomical structure development and protein K63-linked ubiquitination. Predicted to act upstream of or within protein ubiquitination. Orthologous to human HECTD1 (HECT domain E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
43
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (28670132..28701283)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (28653169..28684320)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene MIS18 binding protein 1 Neighboring gene HEAT repeat containing 5a Neighboring gene adaptor related protein complex 4 subunit sigma 1 Neighboring gene striatin, calmodulin binding protein 3 Neighboring gene coagulation factor C homolog, cochlin (Limulus polyphemus)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • FLJ11186, MGC123053

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase HECTD1
NP_001002504.2
XP_009291386.1
XP_009291387.1
XP_009291388.1
XP_009291389.1
XP_009291390.1
XP_009291391.1
XP_009291392.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002504.2 → NP_001002504.2  E3 ubiquitin-protein ligase HECTD1

    See identical proteins and their annotated locations for NP_001002504.2

    Status: PROVISIONAL

    Source sequence(s)
    AL593845
    UniProtKB/TrEMBL
    A0A8M1N0I1, Q8JFV5
    Related
    ENSDARP00000139204.1, ENSDART00000159067.2
    Conserved Domains (7) summary
    smart00119
    Location:2121 → 2573
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:2097 → 2574
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06701
    Location:1277 → 1335
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    cl23730
    Location:1107 → 1240
    F5_F8_type_C; F5/8 type C domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    28670132..28701283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009293111.3 → XP_009291386.1  E3 ubiquitin-protein ligase HECTD1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AJX0
    Conserved Domains (7) summary
    smart00119
    Location:2130 → 2582
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:2106 → 2583
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06701
    Location:1277 → 1335
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    cl23730
    Location:1107 → 1240
    F5_F8_type_C; F5/8 type C domain

  2. XM_009293114.3 → XP_009291389.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

    UniProtKB/TrEMBL
    A0A8M3AJ23
    Conserved Domains (7) summary
    smart00119
    Location:2069 → 2521
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:2045 → 2522
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06701
    Location:1277 → 1335
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    cl23730
    Location:1107 → 1240
    F5_F8_type_C; F5/8 type C domain

  3. XM_009293112.3 → XP_009291387.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

    UniProtKB/TrEMBL
    A0A2R8PW57, A0A8M3AUC7
    Related
    ENSDARP00000145151.1, ENSDART00000182851.1
    Conserved Domains (7) summary
    smart00119
    Location:2115 → 2567
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:2091 → 2568
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06701
    Location:1277 → 1335
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    cl23730
    Location:1107 → 1240
    F5_F8_type_C; F5/8 type C domain

  4. XM_009293115.3 → XP_009291390.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

    UniProtKB/TrEMBL
    A0A0R4IGL6, A0A8M3B2H1
    Related
    ENSDARP00000133558.1, ENSDART00000164981.2
    Conserved Domains (7) summary
    smart00119
    Location:2054 → 2506
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:2030 → 2507
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06701
    Location:1277 → 1335
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    cl23730
    Location:1107 → 1240
    F5_F8_type_C; F5/8 type C domain

  5. XM_009293117.3 → XP_009291392.1  E3 ubiquitin-protein ligase HECTD1 isoform X7

    UniProtKB/TrEMBL
    A0A8M3AUD5
    Conserved Domains (7) summary
    smart00119
    Location:2068 → 2520
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:2044 → 2521
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06701
    Location:1277 → 1321
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    cl23730
    Location:1107 → 1240
    F5_F8_type_C; F5/8 type C domain

  6. XM_009293113.3 → XP_009291388.1  E3 ubiquitin-protein ligase HECTD1 isoform X3

    UniProtKB/TrEMBL
    A0A8M3ARF8
    Conserved Domains (7) summary
    smart00119
    Location:2083 → 2535
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:2059 → 2536
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06701
    Location:1277 → 1321
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    cl23730
    Location:1107 → 1240
    F5_F8_type_C; F5/8 type C domain

  7. XM_009293116.3 → XP_009291391.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

    UniProtKB/TrEMBL
    A0A8M3AJX5
    Conserved Domains (5) summary
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06701
    Location:1277 → 1302
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    cl23730
    Location:1107 → 1240
    F5_F8_type_C; F5/8 type C domain
Nucleotide Protein
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