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slc12a8 solute carrier family 12 member 8 [ Danio rerio (zebrafish) ]

Gene ID: 100000006, updated on 27-Mar-2024

Summary

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Official Symbol
slc12a8provided by ZNC
Official Full Name
solute carrier family 12 member 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5654
See related
Ensembl:ENSDARG00000074384 AllianceGenome:ZFIN:ZDB-GENE-030131-5654
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi11e03; wu:fi11e03; si:dkey-101k6.7
Summary
Predicted to enable potassium:chloride symporter activity. Acts upstream of or within cilium assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human SLC12A8 (solute carrier family 12 member 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See slc12a8 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (38642016..38682255)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (38832876..38872453)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene sorting nexin 4 Neighboring gene zinc finger protein 148 Neighboring gene heart development protein with EGF-like domains 1 Neighboring gene taste receptor, type 2, member 201, tandem duplicate 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effects of β-diketone antibiotic mixtures on behavior of zebrafish (Danio rerio). Wang X, et al. Chemosphere, 2016 Feb. PMID 26595314
  2. Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Shim H, et al. Nucleic Acids Res, 2016 Nov 16. PMID 27903883, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables chloride:monoatomic cation symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell volume homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 12 member 8
Names
solute carrier family 12 (potassium/chloride transporters), member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128277.1 → NP_001121749.1  solute carrier family 12 member 8

    See identical proteins and their annotated locations for NP_001121749.1

    Status: PROVISIONAL

    Source sequence(s)
    BX255930, CR933561
    UniProtKB/TrEMBL
    A0A8M1NJU0, A9C3V4
    Related
    ENSDARP00000122480.1, ENSDART00000135774.3
    Conserved Domains (1) summary
    TIGR00930
    Location:21 → 389
    2a30; K-Cl cotransporter

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    38642016..38682255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167802.4 → XP_005167859.1  solute carrier family 12 member 8 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BF89
    Conserved Domains (1) summary
    TIGR00930
    Location:32 → 400
    2a30; K-Cl cotransporter
Nucleotide Protein
Heading Accession and Version

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