GEO DataSets

Expression profiling of brain left hippocampi from 12 month old Tg2576 transgenics overexpressing the amyloid precursor protein with the Swedish mutation (APPSw). APPSw linked to the early-onset Alzheimer's disease. Tg2576 express neuroprotective genes that prevent neuronal cell loss.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL81

Series:

GSE1556

4 Samples

Download data

(Submitter supplied) Gene expression changes in mice overexpressing amyloid precursor protein with the Swedish mutation (Tg2576; APPSw). The gene expression levels in male 12 month-old APPSw mice (GSM26708, GSM26709) were compared to those in male nontransgenic littermate control mice (GSM26706, GSM26707). Data were analyzed with MAS 5.0 and scaled to 2500.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS811

Platform:

GPL81

4 Samples

Download data

(Submitter supplied) Gene expression changes induced by alpha-secretase cleaved amyloid precursor protein (sAPPalpha) in organotypic hippocampal slice cultures of male, postnatal day 15 mice (C57B6/SJL). Hippocampal slice cultures were treated with phosphate buffered saline (GSM26700, GSM26701, GSM26702) or 1 nM sAPPalpha (GSM26703, GSM26704, GSM26705) for 24 h. Each sample consists of total RNA isolated from 8-12 slices from 4 mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS809

Platform:

GPL81

6 Samples

Download data

Expression profiling of hippocampal slice cultures treated with 1 nM alpha-secretase cleaved amyloid precursor protein (sAPPalpha) for 24 hours. Hippocampi obtained from 15 day postnatal C57B6/SJL males. Results provide insight into the neuroprotective activity of sAPPalpha.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL81

Series:

GSE1555

6 Samples

Download data

(Submitter supplied) Beyond deficits in hippocampal-dependent episodic memory, Alzheimer’s Disease (AD) features sensory impairment in visual cognition consistent with extensive neuropathology in the retina. 12A12 is a monoclonal cleavage specific antibody (mAb) which in vivo selectively neutralizes the AD-relevant, harmful N-terminal 20-22kDa tau fragment(s) (i.e NH2htau) without altering the full-length normal protein. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25723

31 Samples

Download data: CHP

(Submitter supplied) Gene expression analysis of 2-month-old APP/APLP2 double-conditional Knockout (N-dCKO) mice and littermate APLP2 knockout controls, APP knockout and wildtype controls.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

16 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

unidentified; Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL21292 GPL21293

104 Samples

Download data: RCC

(Submitter supplied) Neuronal or glial cell fates related gene expression from single cells with variety of sAPPa or total Aβ secretion profiles were presented here.

Organism:

Homo sapiens; unidentified

Type:

Expression profiling by array

Platform:

GPL21292

32 Samples

Download data: RCC

(Submitter supplied) Neuronal or glial cell fates related gene expression from single cells with variety of sAPPa or total Aβ secretion profiles were presented here.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL21293

72 Samples

Download data: RCC

(Submitter supplied) Early-onset Alzheimer’s disease-like pathology in Down syndrome (DS, trisomy 21) is commonly attributed to an increased dosage of the amyloid precursor protein (APP) gene. To test this central tenet of the amyloid-cascade hypothesis we deleted the supernumerary copy of the APP gene in trisomic DS iPSC, or upregulated APP expression in euploid human pluripotent stem cell lines with dCas9-VP64, and subjected these lines to prolonged cortical neural differentiation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

34 Samples

Download data: TXT

(Submitter supplied) Nsmce1 (NSE1 Homolog, SMC5-SMC6 Complex Component) is a Protein Coding gene, it was reported to function not only in positive regulation of response to DNA damage stimulus but also in the neurological diseases and disorders.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21493

4 Samples

Download data: TXT

(Submitter supplied) A member of the growing family of mammalian RING E3-ubiquitin ligases praja2 (Pja2) was reported to function not only in several types of cancer but also in the neurological diseases and disorders. As a result, the expression of App, Mapt and Gsap could be inhibited by Pja2 overexpression and activated by the knockdown of Pja2. RNA sequencing (RNA-seq) was then used to evaluate and quantify the transcriptomes in response to the overexpression of Pja2 in mouse hippocampal neuronal HT-22 cells.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21493

4 Samples

Download data: TXT