GEO DataSets

Analysis of cortex from SHARP1/2 double null mutants at ZT4 (wake phase) and ZT16 (sleep phase). bHLH transcription factors SHARP1 (DEC2, BHLHE41) and SHARP2 (DEC1, BHLHE40) are circadian modulators. Results provide insight into the molecular contributions of SHARP1/SHARP2 to the sleep-wake cycle.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 time sets

Platform:

GPL81

Series:

GSE59941

8 Samples

Download data: CEL

(Submitter supplied) Gene expression in forebrain structures change during day and night depending on circadian and rest-activity cycles. Clock genes have been shown to be involved in the control of circadian and sleep-wake control. In this study, we aimed at studying the consequences of loss of SHARP1 (DEC2/BHLHE40) and SHARP2 (DEC1/BHLHE41) on cortical gene expression at rest (ZT4) and activity (ZT16) phases.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5423

Platform:

GPL81

8 Samples

Download data: CEL

(Submitter supplied) Background: The prefrontal cortex is important in regulating sleep and mood. Diurnally regulated genes in the prefrontal cortex may be controlled by the circadian system, by the sleep-wake states, or by cellular metabolism or environmental responses. Bioinformatics analysis of these genes will provide insights into a wide-range of pathways that are involved in the pathophysiology of sleep disorders and psychiatric disorders with sleep disturbances. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3080

Platform:

GPL1261

12 Samples

Download data: CEL

Analysis of prefrontal cortices from C57BL/6J animals at 4 Zeitgeber time (ZT) points, 3 and 9 hrs after lights on (ZT3 and ZT9) and 3 and 9 hs after lights off (ZT15 and ZT21). The prefrontal cortex is important in regulating sleep and mood. Results provide insight into genes with diurnal rhythms.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 time sets

Platform:

GPL1261

Series:

GSE9471

12 Samples

Download data: CEL

(Submitter supplied) Tissues in multicellular organisms are ‘serviced’ by resident macrophages, which perform both generic and tissue-specific functions. The latter relies on unique tissue-specific molecular programs induced by signals from the microenvironment and executed through a combinatorial action of tissue-specific and broadly expressed transcriptional regulators. Here, we identify the transcription factors Bhlhe40 and Bhlhe41 as novel regulators of alveolar macrophages (AMs) – a population that provides the first line of immune defense and executes homeostatic functions in lung alveoli. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL19057 GPL17021

18 Samples

Download data: BIGWIG, XLSX