GEO DataSets

Analysis of adipose stroma from nulliparous, lactating and involuting mammary glands. Pregnancy-associated breast cancers (PABCs) diagnosed during lactation are generally more aggressive with poorer prognosis. Results provide insight into the role of stromal changes in the pathogenesis of PABCs.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 development stage sets

Platform:

GPL6246

Series:

GSE53044

9 Samples

Download data: CEL

(Submitter supplied) Adipose stroma in the mouse mammary gland undergoes remodeling throughout the 5 stages of development. These include nulliparous (virgin;never been pregnant), pregnant, lactating, involuting and regressed. We used a microarry to determine the changes in gene expression during gland development.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5361

Platform:

GPL6246

9 Samples

Download data: CEL

(Submitter supplied) Examination of an interaction between adipocytes and MCF7 to identify the genes associated with invasion of carcinoma cells into adjescent adipocytes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL14550

6 Samples

Download data: TXT

(Submitter supplied) Insulin like growth factor binding protein 7, Igfbp7, is a secreted protein that in addition to modulating insulin and insulin-like growth factor signaling, it acts as a tumor suppressor gene in breast and other cancers. To elucidate the role of Igfbp7 in regulating the proliferation and differentiation of mammary epithelial cells, we examined the growth and differentiation of mammary gland through different stages of its development in Igfbp7-null mice. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15907

2 Samples

Download data: TXT, WIG

(Submitter supplied) Fibroblasts within the mammary tumor microenvironment are active participants in carcinogenesis mediating both tumor initiation and progression. Our group has previously demonstrated that genetic loss of PTEN in mammary fibroblasts induces an oncogenic secretome that remodels the extracellular milieu accelerating ErbB2-driven mammary tumor progression. While these prior studies highlighted a tumor suppressive role for stromal PTEN, how the adjacent normal epithelium transforms in response to PTEN loss was not previously addressed. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL20775

6 Samples

Download data: CEL

(Submitter supplied) Here, we use spatially and time controlled induction of Elf5 within the mammary epithelium in the context of the luminal MMTV-PyMT mouse mammary cancer to study tumour progression mechanisms associated to the specification of the basal breast cancer subtype at single-cell resolution.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

11 Samples

Download data: MTX, TSV

(Submitter supplied) The mouse mammary gland undergoes severe morphological changes during each pregnancy cycle. These are controlled by epithelial as well as stromal factors, including fibroblasts. This project aimed to identify factors that are expressed in mammary fibroblasts during early pregnancy (day3) when the first morphological changes become microscopically visible.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL17543

6 Samples

Download data: TXT

(Submitter supplied) Investigating the gene expression profile changes upon β-hydroxybutyrate treatment in MDA-MB-231 breast cancer cells w/ or w/o MCT2 expression

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16951

4 Samples

Download data: GPR

(Submitter supplied) We modeled two types of breastfeeding behaviors in wild type FVB/N mice: (1) normal or gradual involution of breast tissue following prolonged breastfeeding and (2) forced or abrupt involution following short-term breastfeeding. To accomplish this, pups were gradually weaned between 28 and 31 days (gradual involution) or abruptly at 7 days postpartum (abrupt involution). FACS was used to relatively quantify mammary epithelial subpopulations. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL21877

4 Samples

Download data: CEL, CHP

(Submitter supplied) Studying composition and developmental mechanisms in mammary gland is crucial for healthy growth of the newborn. Here, we constructed the largest transcriptomic dataset of mammary gland cells thus far. The dataset captured 126,829 high-quality nuclei from adipocytes, endothelial cells, epithelial cells, fibroblasts cells, immune cells, myoepithelial cells and precursor cells at five timepoint of mammary development. more...

Organism:

Sus scrofa

Type:

Expression profiling by high throughput sequencing; Other

Platforms:

GPL26351 GPL22918

14 Samples

Download data: MTX, PNG, TSV

(Submitter supplied) There is a lack of systematic investigations of large-scale transcriptome patterns associated with normal breast development. Herein, we profiled whole-transcriptome (by microarrays) of normal mammary glands in female Sprague-Dawley rats, an animal model widely used in breast cancer research, across six distinctive developmental stages – pre-pubertal, peri-pubertal, pubertal, lactation, and adult parous and age-matched nulliparous.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL17117

33 Samples

Download data: CEL

(Submitter supplied) Mammary gland from F1 CO female offspring exhibited enhanced development when transplanted into OID females [OID(CO-MG)], as shown by higher mammary gland area, epithelial branching and epithelial elongation, compared to CO females that received a CO mammary gland [CO(CO-MG)]. Similarly, mammary tumors from F1 CO female offspring transplanted into OID females [OID(CO.T)] displayed improved growth with higher proliferation index and lower apoptotic rates. more...

Organism:

Mus musculus

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL17021

15 Samples

Download data: TXT

(Submitter supplied) The goal of this study is to compare the gene expression profiles of cancer cells isolated from tumors arising in lean or obese animals.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

19 Samples

Download data: TXT

(Submitter supplied) Obesity is a major risk factor for adverse outcomes in breast cancer. Maguire, Ackerman et al. reveal Gatm and Acsbg1 as molecular regulators of obesity-driven breast cancer progression. They further show that in obesity creatine is a key metabolite in the crosstalk between adipocytes and breast tumors.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

24 Samples

Download data: TXT

(Submitter supplied) Purpose: The goals of this study are to determine adipocyte de-differentiation and the fate of these de-differentiated cells in breast tumor. Methods: Library prepared followed by 10X Genomics standard protocol. Transcriptome was generated by high throughput sequencing.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

2 Samples

Download data: MTX, TSV

(Submitter supplied) The aim of this study is to assess the impact of cabergoline on the intensity of short-term post-lactational involution and to explore long-term alterations in the epithelial dynamics of the glandular component in Brca1/P53-deficient mice. This study also delves into the transcriptomic changes associated with these processes. To further investigate the molecular changes occurring at these temporal points, RNA sequencing (RNA-seq) was conducted 1 day after post-lactation involution and again at 60 days.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

25 Samples

Download data: XLSX