Similar studies for GEO DataSets (Select 5293) - GEO DataSets

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Items: 20

Select item 52931.

Maternal western diet effect on post-weaning western diet fed offspring liver

Analysis of liver of C57BL/6J male offspring exposed prenatally to a western-style diet (rich in energy, fat, cholesterol) or a low-fat diet and then a post-weaning western diet. Results provide insight into the role of maternal western diet in the development of liver disease in offspring.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 protocol sets

Platform:: GPL6887
Series:: GSE44901
11 Samples

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DataSet

Accession:: GDS5293

ID:: 5293

Select item 2000449012.

Maternal western diet primes susceptibility to hepatic inflamation in adult male mouse offspring

(Submitter supplied) Background & Aims: The influences of the maternal diet during gestation has been suggested to be involved in the development of different aspects of the metabolic syndrome. In our mouse model we characterised the role of maternal western diet in the development of non-alcoholic fatty liver disease (NAFLD) in the offspring. Methods: Female mice were fed either a western (W) or low-fat control (L) semi-synthetic diet before and during gestation and lactation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS5293 GDS5342
Platform:: GPL6887
22 Samples

Download data: TXT

Series

Accession:: GSE44901

ID:: 200044901

Select item 53423.

Maternal western diet effect on post-weaning low-fat diet fed offspring liver

Analysis of liver of C57BL/6J male offspring exposed prenatally to a western-style diet (rich in energy, fat, cholesterol) or a low-fat diet and then a post-weaning low-fat diet. Results provide insight into the role of maternal western diet in the development of liver disease in offspring.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 protocol sets

Platform:: GPL6887
Series:: GSE44901
11 Samples

Download data

DataSet

Accession:: GDS5342

ID:: 5342

Select item 2000480144.

Gene expression in the liver, effect of maternal high-fat diet during or prior to pregnancy

(Submitter supplied) The present study aimed to examine the effect of high-fat diet prior to pregnancy on the liver of mouse offspring. Female C57BL/6J mice were fed a normal chow (15.2% fat by energy) (CTR and CTR-PP groups) or a high-fat chow (31.2% fat by energy) (HFD and HFD-PP groups) for 3−4 weeks and then mated with male C57BL/6J mice fed normal chow. Some mothers continued on the same diet until pups reached 21 days of age (CTR and HFD), and others were fed the different chows from gestational day 0 (CTR-PP and HFD-PP) to determine the effects of a high-fat diet during the pre-pregnancy period in HFD-PP/CTR and HFD/CTR-PP comparisons.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
10 Samples

Download data: CSV

Series

Accession:: GSE48014

ID:: 200048014

Select item 2000463595.

Maternal Western-style high fat diet induces sex-specific physiological and molecular changes in two-week-old mouse offspring

(Submitter supplied) Maternal diet is associated with the development of metabolism-related and other non-communicable diseases in offspring. Underlying mechanisms, functional profiles, and molecular markers are only starting to be revealed. Here, we explored the physiological and molecular impact of maternal Western-style diet on the liver of male and female offspring. C57BL/6 dams were exposed to either a low fat/low cholesterol diet (LFD) or a Western-style high fat/high cholesterol diet (WSD) for six weeks before mating, as well as during gestation and lactation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4774
Platform:: GPL11533
27 Samples

Download data: CEL

Series

Accession:: GSE46359

ID:: 200046359

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 47746.

Maternal western-style high fat diet effect on liver of two-week-old offspring

Analysis of livers from PD14 offspring of C57BL/6 dams fed a Western-style high fat/high cholesterol diet (WSD). Maternal diet is associated with the development of metabolism-related diseases in offspring. Results provide insight into molecular impact of maternal WSD on male and female offspring.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 gender, 2 protocol sets

Platform:: GPL11533
Series:: GSE46359
27 Samples

Download data: CEL

DataSet

Accession:: GDS4774

ID:: 4774

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2002421897.

Maternal Western Diet Programs Cardiometabolic Dysfunction and Hypothalamic Inflammation via Epigenetic Mechanisms Predominantly in the Male Offspring

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL21626 GPL19057
74 Samples

Download data: COV

Series

Accession:: GSE242189

ID:: 200242189

PubMed Full text in PMC Similar studies

Select item 2002421888.

Maternal Western Diet Programs Cardiometabolic Dysfunction and Hypothalamic Inflammation via Epigenetic Mechanisms Predominantly in the Male Offspring [miRNA-seq]

(Submitter supplied) Maternal exposure during pregnancy is a strong determinant of offspring health outcomes. Such exposures induce changes in the offspring epigenome resulting in gene expression and functional changes. In this study, we investigated the effect of maternal Western hypercaloric diet (HCD) programming during the perinatal period and its effect on neuronal plasticity and cardiometabolic health in adult offspring. more...

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL21626
25 Samples

Download data: XLSX

Series

Accession:: GSE242188

ID:: 200242188

PubMed Full text in PMC Similar studies

Select item 2002421879.

Maternal Western Diet Programs Cardiometabolic Dysfunction and Hypothalamic Inflammation via Epigenetic Mechanisms Predominantly in the Male Offspring [RNA-seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21626
25 Samples

Download data: CSV

Series

Accession:: GSE242187

ID:: 200242187

PubMed Full text in PMC Similar studies

Select item 20024218610.

Maternal Western Diet Programs Cardiometabolic Dysfunction and Hypothalamic Inflammation via Epigenetic Mechanisms Predominantly in the Male Offspring [Methyl-seq]

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL19057
24 Samples

Download data: COV

Series

Accession:: GSE242186

ID:: 200242186

PubMed Full text in PMC Similar studies

Select item 20001594011.

Sex-Dependent Programming of Glucose and Fatty Acid Metabolism in Mouse Offspring by Maternal Protein Restriction

(Submitter supplied) Analysis of glucose and Lipid metabolism in male and female offspring after protein restriction of the mother Male offspring showed features of metabolic syndrome after receiving a high fat diet, regardless of the diet of the dam. Glucose and lipid metabolism in male offspring was unaltered. Insulin sensitivity and hepatic fatty acid storage in female offspring of low-protein-fed dams changed in such a way that it resembled the male pattern of insulin sensitivity and hepatic fatty acid storage. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL6103 GPL6885
32 Samples

Download data: TXT

Series

Accession:: GSE15940

ID:: 200015940

Select item 20006320812.

Epigenomic profiling in visceral white adipose tissue of offspring of mice exposed to late gestational sleep fragmentation

(Submitter supplied) Background: Late gestational sleep fragmentation (LG-SF) is one of the major perturbations associated with sleep apnea and other sleep disorders during pregnancy. Objectives: To investigate the effects of late LG-SF on the epigenome of visceral white adipose tissue (VWAT) in the offspring. Methods: Time-pregnant mice were exposed to LG-SF or control sleep (LG-SC) conditions during the last 6 days of gestation. more...

Organism:: Mus musculus

Type:: Methylation profiling by genome tiling array

Platform:: GPL5811
16 Samples

Download data: CEL, TXT

Series

Accession:: GSE63208

ID:: 200063208

PubMed Full text in PMC Similar studies

Select item 20009971813.

Primate fetal hepatic response to maternal obesity: epigenetic signaling pathways and lipid accumulation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Papio hamadryas

Type:: Expression profiling by array; Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL15440 GPL6947
22 Samples

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Series

Accession:: GSE99718

ID:: 200099718

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009971714.

Primate fetal hepatic response to maternal obesity: epigenetic signaling pathways and lipid accumulation [miRNA-seq]

(Submitter supplied) The liver is a major site for synthesis, storage and redistribution of carbohydrates, proteins and lipids. In addition, it is well-known that maternal obesity (MO) increases risk of offspring cardiovascular disease (CVD), diabetes and obesity. However, the mechanisms by which the MO intrauterine environment predisposes offspring to CVD and metabolic dysregulation are unknown. The goal of this study was to assess the impact of MO on primate fetal liver and identify underlying molecular mechanisms by which MO increases disease risk. more...

Organism:: Papio hamadryas

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL15440
11 Samples

Download data: FA, XLSX

Series

Accession:: GSE99717

ID:: 200099717

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009755415.

Primate fetal hepatic response to maternal obesity: epigenetic signaling pathways and lipid accumulation [gene expression]

Organism:: Papio hamadryas; Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
11 Samples

Download data: TXT

Series

Accession:: GSE97554

ID:: 200097554

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007743216.

Alterations in the hepatic epigenome in mice exposed to a maternal high fat diet in utero

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Methylation profiling by genome tiling array

Platforms:: GPL21388 GPL21389
8 Samples

Download data: CALLS, PAIR, TXT, WIG

Series

Accession:: GSE77432

ID:: 200077432

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007743117.

Alterations in the hepatic gene expression in mice exposed to a maternal high fat diet in utero [Microarray]

(Submitter supplied) Exposure to a high fat (HF) diet in utero is associated with increased incidence of cardiovascular disease, diabetes and metabolic syndrome later in life. However, the molecular basis of this enhanced susceptibility for metabolic disease is poorly understood. We used gene expression microarray to examine mRNA expression patterns in liver of offspring exposed to a Control or HF maternal diet. WT mice were fed a Control (9.5% fat, 3.59 kcal/g) or HF (35.5% fat, 5.29 kcal/g) diet for 2 wk before mating, throughout pregnancy and lactation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21389
2 Samples

Download data: CALLS, PAIR

Series

Accession:: GSE77431

ID:: 200077431

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007743018.

Alterations in the hepatic epigenome in mice exposed to a maternal high fat diet in utero [HELP]

(Submitter supplied) Exposure to a high fat (HF) diet in utero is associated with increased incidence of cardiovascular disease, diabetes and metabolic syndrome later in life. However, the molecular basis of this enhanced susceptibility for metabolic disease is poorly understood. We performed genome-wide DNA methylation analysis to examine DNA methylation patterns in liver of offspring exposed to a Control or HF maternal diet. more...

Organism:: Mus musculus

Type:: Methylation profiling by genome tiling array

Platform:: GPL21388
6 Samples

Download data: TXT, WIG

Series

Accession:: GSE77430

ID:: 200077430

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022010219.

Maternal Western Diet is Associated with Distinct Preclinical Pediatric NAFLD Phenotypes in Juvenile Nonhuman Primate Offspring [Liver RNA-seq]

(Submitter supplied) Pediatric nonalcoholic fatty liver disease (NAFLD) has distinct and variable pathology that affects up to 10% of children, yet causation remains unclear. We have shown that maternal Western- style diet (mWSD) compared with chow diet (mCD) consumption in nonhuman primates (NHP) produces hepatic injury and steatosis in fetal offspring. Here, we define the role of mWSD and postweaning WSD (pwWSD) exposures on potential molecular mechanisms linked to NAFLD development in a cohort of 3-year-old (3YO) juvenile NHP offspring exposed to mCD or mWSD followed by CD or WSD after weaning. more...