Similar studies for GEO DataSets (Select 5262) - GEO DataSets

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Items: 10

Select item 52621.

Interleukin 4, interleukin 13 and tumor necrosis factor-α effect on plastic-cultured IMR-90 lung fibroblast cells

Analysis of IMR-90 cells cultured on plastic and treated with IL-4, IL-13 or TNFα. Type 2 inflammatory processes mediated by IL-4 and IL-13 are implicated in pathologic lung fibrogenesis. Results provide insight into molecular mechanisms underlying the onset and maintenance of pulmonary fibrosis.

Organism:: Homo sapiens

Type:: Expression profiling by array, log2 ratio, 4 agent sets

Platform:: GPL6480
Series:: GSE47542
12 Samples

Download data: TXT

DataSet

Accession:: GDS5262

ID:: 5262

Select item 2000475422.

IMR90 lung fibroblasts treated with IL-4 or IL-13

(Submitter supplied) IL-4 and IL-13 are cytokines involved in type 2 immune responses involved in atopic asthma and other diseases. They have a partially overlapping set of cognate receptors whose roles are incompletely understood. Here we explore the effects of these cytokines on lung fibroblasts in order to assess the global similarities and contrasts in the genes whose expression their ligation modulates.

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS5261 GDS5262
Platform:: GPL6480
24 Samples

Download data: TXT

Series

Accession:: GSE47542

ID:: 200047542

Select item 2000475383.

Myeloid cells or lung fibroblasts treated with IL-4 or IL-13

(Submitter supplied) IL-4 and IL-13 are cytokines involved in type 2 immune responses involved in atopic asthma and other diseases. They have a partially overlapping set of cognate receptors whose roles are incompletely understood. Here we explore the effects of these cytokines on various cells related to human lung disease in order to assess the global similarities and contrasts in the genes whose expression their ligation modulates.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13497
65 Samples

Download data: TXT

Series

Accession:: GSE47538

ID:: 200047538

Select item 2000475274.

Effects of anti-IL13RA mAbs on IL-4 or IL-13 signalling

(Submitter supplied) IL-4 and IL-13 are cytokines involved in type 2 immune responses involved in atopic asthma and other diseases. They have a partially overlapping set of cognate receptors whose roles are incompletely understood. Here we explore the effects of blocking one or both subunits of the IL-13 alpha receptor on the action of these cytokines on IMR-90 lung fibroblast cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
35 Samples

Download data: TXT

Series

Accession:: GSE47527

ID:: 200047527

Select item 52615.

Interleukin 4, interleukin 13 and tumor necrosis factor-α effect on Matrigel-cultured IMR-90 lung fibroblast cells

Analysis of IMR-90 cells cultured on Matrigel and treated with IL-4, IL-13 or TNFα. Type 2 inflammatory processes mediated by IL-4 and IL-13 are implicated in pathologic lung fibrogenesis. Results provide insight into molecular mechanisms underlying the onset and maintenance of pulmonary fibrosis.

Organism:: Homo sapiens

Type:: Expression profiling by array, log2 ratio, 4 agent sets

Platform:: GPL6480
Series:: GSE47542
12 Samples

Download data: TXT

DataSet

Accession:: GDS5261

ID:: 5261

Select item 2000563386.

TNF-alpha and IL-17 synergize to inhibit IL-13 bioactivity via IL-13Ra2 induction in human lung fibroblasts

(Submitter supplied) IL-17 and TNF-alpha synergistically induce surface expression of IL-13Ra2 on primary lung fibroblasts, rendering them unresponsive to IL-13. Neutralizing antibodies to IL-13Ra2 restored IL-13-mediated signaling and transcriptome studies confirmed IL-13Ra2 is an IL-13 decoy receptor.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
23 Samples

Download data: TXT

Series

Accession:: GSE56338

ID:: 200056338

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000157397.

Il13-stimulation of human paSMCs

(Submitter supplied) Idiopathic pulmonary arterial hypertension (IPAH) is characterized by medial hypertrophy due to pulmonary arterial smooth muscle cell (paSMC) hyperplasia. Interleukin (IL)-13 is a potent regulator of tissue fibrosis and remodelling, and its effects are dependent on the cell-type specific expression of the IL-13 receptor isotypes IL-4Rα, IL-13Rα1, and IL-13Rα2. In order to identify the possible mechanism how IL-13 can exert its antiproliferative effect on paSMC microarray analysis was performed. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL1708
6 Samples

Download data: GPR

Series

Accession:: GSE15739

ID:: 200015739

Select item 2001049388.

Hierarchical control of the IL-13 signals by STAT6 and SOX11 in lung fibroblasts

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL20844 GPL16699
6 Samples

Download data: TXT

Series

Accession:: GSE104938

ID:: 200104938

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001049379.

Hierarchical control of the IL-13 signals by STAT6 and SOX11 in lung fibroblasts (NHLF cells)

(Submitter supplied) We sought to dissect SOX11-dependent and -independent genes in IL-13–inducible genes in primary human lung fibroblasts

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL20844
4 Samples

Download data: TXT

Series

Accession:: GSE104937

ID:: 200104937

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010493610.

Hierarchical control of the IL-13 signals by STAT6 and SOX11 in lung fibroblasts (MRC-5 cells)

(Submitter supplied) To identify candidates for trans-acting factors for IL-13–induced genes in lung fibroblasts, we searched transcriptional factors among IL-13–inducible molecules in lung fibroblasts