GEO DataSets

Analysis of clear cell renal cell carcinoma (ccRCC) cells treated with A939572, a stearoyl-CoA desaturase 1 (SCD1) inhibitor. SCD1 is overexpressed in ccRCC.Results provide insight into the role of SCD1 in the pathogenesis of ccRCC.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 4 cell line sets

Platform:

GPL570

Series:

GSE41485

8 Samples

Download data: CEL

(Submitter supplied) Presently, there is a deficiency of effective therapies designed to target clear cell renal cell carcinoma (ccRCC), with poor prognosis resulting in patients with advanced disease. Additionally, there is a lack of molecular factors which can be remedially targeted resulting in tumor specific inhibition, and therefore current therapeutic approaches often produce adverse side effects in patients. We identified that Stearoyl-CoA desaturase 1 (SCD1) was consistently overexpressed in patient ccRCC samples, and further investigation of SCD1 as a potential molecular target for ccRCC intervention utilizing a SCD1 inhibitor (A939572) resulted in tumor specific growth inhibition and induction of cell death. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5094

Platform:

GPL570

8 Samples

Download data: CEL

(Submitter supplied) We kept 2 types of primary xenograft models (KURC;Kyoto University Renal Cancer-1,3) derived from human renal cell carcinoma tissues, and 10 mg/kg of temsirolimus or vehicle was intraperitoneally administered.We performed microarray analysis to compare the gene expression profile of temsirolimus-treated primary xenograft tumors with that of vehicle-treated.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16686

9 Samples

Download data: CEL

(Submitter supplied) We kept a primary xenograft models (KURC;Kyoto University Renal Cancer-3) derived from human renal cell carcinoma tissues, and 10 mg/kg of temsirolimus or vehicle was intraperitoneally administered.We performed DNA methylation analysis to compare the methylation profile of temsirolimus-treated primary xenograft tumors with that of vehicle-treated.

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL13534

2 Samples

Download data: IDAT, TXT

(Submitter supplied) Currently there is a lack of effective therapies which result in long-term durable response for patients presenting with anaplastic thyroid carcinoma (ATC), a very rare and lethal variant of thyroid cancer. ATC is resistant to chemotherapy, radiation, and targeted therapies currently available. In an effort to identify novel tumor-specific therapeutic targets, we performed high throughput gene array analysis screening numerous patient ATC tumor tissues, and compared their gene expression levels to matched and unmatched normal thyroid tissue samples.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

25 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL9101

160 Samples

Download data: CEL, TXT

(Submitter supplied) Systematic somatic mutation screening of 4000 genes in human clear cell renal cell carcinoma. Information on corresponding somatic mutations in each sample can be found at http://www.sanger.ac.uk/genetics/CGP/Studies/.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL9101

115 Samples

Download data: CEL, TXT

(Submitter supplied) Systematic somatic mutation screening of 4000 genes in human clear cell renal cell carcinoma. Information on corresponding somatic mutations in each sample can be found at http://www.sanger.ac.uk/genetics/CGP/Studies/. These samples were run at a different facility than VARI - scmmlab.com

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL9101

45 Samples

Download data: CEL, TXT

(Submitter supplied) Aberrant activation of FGFR3 via overexpression or mutation is a frequent feature of bladder cancer; however, its molecular and cellular consequences and functional relevance to carcinogenesis are not well understood. In this study with a bladder carcinoma cell line expressing inducible FGFR3 shRNAs, we sought to identiy transcriptional targets of FGFR3 and investigate their contribution to bladder cancer development.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4454

Platform:

GPL570

24 Samples

Download data: CEL

Analysis of bladder cancer cell line RT112 subjected to doxycycline-inducible, shRNA knockdown of FGFR3. Knockdown of FGFR3 in RT112 cells significantly attenuates tumor growth in vitro and in vivo. Results provide insight into the molecular mechanisms underlying FGFR3-driven bladder cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 genotype/variation, 2 protocol sets

Platform:

GPL570

Series:

GSE41035

24 Samples

Download data: CEL

(Submitter supplied) The purpose of this experiment is to search for the downstream target of SCD1

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18460

4 Samples

Download data: TXT

(Submitter supplied) We established 3 types of primary xenograft models (KURC;Kyoto University Renal Cancer-1,2,3) derived from human renal cell carcinoma tissues, and 40 mg/day of sunitinib was orally administered. We performed microarray analysis to compare the gene expression profile of sunitinib-treated primary xenograft tumors (sensitive or resistant status) with that of vehicle-treated.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5815

Platform:

GPL6244

9 Samples

Download data: CEL

Analysis of Kyoto University Renal Cancer (KURC) xenograft tumor models, KURC1, KURC2, KURC3, treated with sunitinib, a small molecule inhibitor of receptor tyrosine kinases that is used to treat RC. Results provide insight into molecular mechanisms underlying acquired sunitinib resistance in RC.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 disease state, 3 individual sets

Platform:

GPL6244

Series:

GSE66346

9 Samples

Download data: CEL

(Submitter supplied) We performed RNA-seq of whole starved cct3A(RNAi) planarians and controls at 72hR.

Organism:

Schmidtea mediterranea

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20150

6 Samples

Download data: XLSX

(Submitter supplied) While early stages of clear cell renal cell carcinoma (ccRCC) are curable, survival outcome for metastatic ccRCC remains poor. The purpose of the current study was to apply a new individualized bioinformatics analysis (IBA) strategy to these transcriptome data in conjunction with Gene Set Enrichment Analysis of the Connectivity Map (C-MAP) database to identify and reposition FDA-approved drugs for anti-cancer therapy. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL3921 GPL9197

8 Samples

Download data: CEL, CHP

(Submitter supplied) The most common subset of renal carcinoma, clear cell renal cell carcinoma (ccRCC), is characterized by accentuated accumulation of neutral lipids in lipid droplets and adipogenic trans-differentiation. Because obesity is a major risk factor in the development of ccRCC, we investigated the role of the adipokines in driving lipid metabolism and tumorigenesis in ccRCC. Through in silico screening, we identified the adipokine chemerin as candidate pro-oncogenic factor that is overexpressed in tumors and prognostic for patient outcome. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

12 Samples

Download data: XLSX