Similar studies for GEO DataSets (Select 4924) - GEO DataSets

Select item 49241.

Glycerol-induced and cardiotoxin-induced models of skeletal muscle regeneration: time course

Analysis of tibialis anterior (TA) muscle of 12 wk old C57BL/6J males injected with glycerol or cardiotoxin (CTX). TA muscle was collected up to 21 days after injection. Results provide insight into the molecular mechanisms underlying skeletal muscle regeneration.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 protocol, 5 time sets

Platform:: GPL1261
Series:: GSE45577
48 Samples

Download data: CEL

DataSet

Accession:: GDS4924

ID:: 4924

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000455772.

Profiling of glycerol- and CTX-induced models of muscle regeneration in mice

(Submitter supplied) Utilizing glycerol and cardiotoxin (CTX) injections in the tibialis anterior muscles of M. musculus provides models of skeletal muscle damages followed by skeletal muscle regeneration. In particular, glycerol-induced muscle regeneration is known to be associated with ectopic adipogenesis. We characterized genome-wide expression profiles of tibialis anterior muscles from wild-type mice injured by either glycerol or CTX injection. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4924
Platform:: GPL1261
48 Samples

Download data: CEL

Series

Accession:: GSE45577

ID:: 200045577

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002004873.

MME+ fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle

(Submitter supplied) Fatty infiltration, the ectopic deposition of adipose tissue within skeletal muscle, is mediated via the adipogenic differentiation of fibro-adipogenic progenitors (FAPs). We used single-nuclei and single-cell RNA sequencing to characterize FAP heterogeneity in patients with fatty infiltration. We identified an MME+ FAP subpopulation which, based on ex vivo characterization as well as transplantation experiments, exhibits high adipogenic potential. more...

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL24247
17 Samples

Download data: MTX, TSV, TXT

Series

Accession:: GSE200487

ID:: 200200487

PubMed Full text in PMC Similar studies

Select item 2001437044.

Single-cell transcriptomic atlas of human donor muscle tissue

(Submitter supplied) The overall objective of the study was to survey the cellular and gene expression heterogeneity of human muscle tissue by single-cell RNA-sequencing.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
10 Samples

Download data: TXT

Series

Accession:: GSE143704

ID:: 200143704

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000860735.

Ciliary Hedgehog signaling restricts injury-induced adipogenesis

(Submitter supplied) Injured skeletal muscle regenerates, but with age or in muscular dystrophies, muscle is replaced by fat. Upon injury, muscle-resident fibro/adipogenic progenitors (FAPs) proliferated and gave rise to adipocytes. These FAPs dynamically produced primary cilia, structures that transduce intercellular cues such as Hedgehog (Hh) signals. Genetically removing cilia from FAPs inhibited intramuscular adipogenesis, both after injury and in a mouse model of Duchenne muscular dystrophy. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: TXT

Series

Accession:: GSE86073

ID:: 200086073

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000925086.

Profiling of mouse Fibro/adipogenic progenitors (FAPs) aging and activation upon skeletal muscle injury

(Submitter supplied) Utilizing glycerol intramuscular injections in M. musculus provides a model of skeletal muscle damage followed by skeletal muscle regeneration. In particular, glycerol-induced muscle injury triggers accute activation of muscle Fibro/Adipogenic Progenitors, also called FAPs. However, aging dramatically impairs FAP function. We characterized genome-wide expression profiles of young and old FAPs in the non-proliferative and activated state, freshly isolated to non-injured or damaged muscles, respectively. more...