Similar studies for GEO DataSets (Select 4895) - GEO DataSets

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Items: 3

Select item 48951.

SIRT1 deficiency effect on the brain

Analysis of brains deficient for SIRT1. SIRT1 is an NAD-dependent protein deacetylase that play a role in numerous metabolic processes in many tissues, including the brain. Results provide insight into the impact of SIRT1 on brain physiology.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL8321
Series:: GSE28790
8 Samples

Download data: CEL

DataSet

Accession:: GDS4895

ID:: 4895

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000287902.

SIRT1 impact on global gene expression in the brain

(Submitter supplied) We compared expression of genes in brains of SIRT1 brain-specific knockouts (BSKO) to those of wild-type littermate controls (WT).

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4895
Platform:: GPL8321
8 Samples

Download data: CEL

Series

Accession:: GSE28790

ID:: 200028790

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001639203.

The role of SIRT1 in regulation of transcription and splicing in mouse embryonic stem cells

(Submitter supplied) SIRT1 is a nuclear enzyme that removes acetyl-groups from target proteins by using NAD+ as a co-substrate. SIRT1 regulates many vital biological processes such as metabolism, stress response, development, and aging. We have previously shown that SIRT1 is critically involved in mouse embryonic stem cell (mESC) maintenance and differentiation in part through modulation of the acetylation status of key transcription factors and their mediated amino acid metabolism and cell signaling. more...