GEO DataSets

Analysis of livers of animals fed a methionine- and choline- deficient, high fat diet (MCD+HF) containing metformin. MCD+HF models non-alcoholic steatohepatitis (NASH). Results provide insight into the feasibility of using metformin, an anti-diabetic drug, to treat NASH without underlying diabetes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 protocol sets

Platform:

GPL1261

Series:

GSE35961

12 Samples

Download data: CEL

(Submitter supplied) Optimal treatment for nonalcoholic steatohepatitis (NASH) has not yet been established, particularly for individuals without diabetes. We examined the effects of metformin, commonly used to treat patients with type 2 diabetes, on liver pathology in a non-diabetic NASH mouse model.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4883

Platform:

GPL1261

12 Samples

Download data: CEL

(Submitter supplied) Background and aims: Here we investigate the role of IL-11 signalling in the pathogenesis of nonalcoholic steatohepatitis (NASH). Methods: HSCs or hepatocytes were stimulated with IL-11 and effects assessed using cellular and high content imaging, immunoblotting, ELISA and invasion assays. Genetic and pharmacological IL-11 gain- or loss-of-function experiments were performed in vitro and in vivo. IL-11 signaling was studied using ERK inhibitors. more...

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL18573 GPL19057

30 Samples

Download data: TXT

(Submitter supplied) The microRNAs expression was markedly altered with the MCD diet.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL16362

8 Samples

Download data: TXT

(Submitter supplied) The microRNAs expression was altered with the treatment of metformin in vivo and several microRNAs induced by metformin also may contribute to suppressed of NASH.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL16362

8 Samples

Download data: TXT

(Submitter supplied) Two months-old Shp flox/flox male mice were injected with either AAV8 expressing Cre recombinase driven by the thyroxine-binding globulin (Tbg) promoter (AAV8-Tbg-Cre) or control AAV8 (AAV8-Tbg-null) and fed chow or a diet enriched in high fat, cholesterol, and fructose (Research diet D09100301: 40 kcal% fat, 2% cholesterol, 20 kcal% fructose, hereafter referred to as HFCF diet) for 3 months. Liver RNA was isolated and submitted to RNA-seq.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15103

12 Samples

Download data: TXT