GEO DataSets

Analysis of brains from SARM-deficient animals infected with the vesicular stomatitis virus (VSV). SARM is a member of the Toll/IL-1R domain-containing adaptor family. VSV is used to study the response to neurotropic viral infections. Results provide insight into the role of SARM in innate immunity.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 infection sets

Platform:

GPL1261

Series:

GSE44331

12 Samples

Download data: CEL, CHP

(Submitter supplied) Sarm-deficient mice are protected from VSV encephalitis and death. Microarray was done to examine genes contributing to this phenotype

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4842

Platform:

GPL1261

12 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) The Toll/IL-1R domain-containing adaptor protein SARM1 is expressed primarily in the brain, where it mediates axonal degeneration. Additional roles for SARM1 in a number of other processes including TLR-signaling, viral infection, chemokine expression, and XAF1 expression have also been described. Here we report defects in the induction of Ccl3, Ccl4, and Ccl5 in Sarm1-/- macrophages, for which we were unable to find mechanistic support. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

4 Samples

Download data: BAM, TXT

(Submitter supplied) The Toll/IL-1R domain-containing adaptor protein SARM1 is expressed primarily in the brain, where it mediates axonal degeneration. Additional roles for SARM1 in a number of other processes including TLR-signaling, viral infection, chemokine expression, and XAF1 expression have also been described. Here we report defects in the induction of Ccl3, Ccl4, and Ccl5 in Sarm1-/- macrophages, for which we were unable to find mechanistic support. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

48 Samples

Download data: TXT

(Submitter supplied) Purpose:The purpose of this study is to measure the gene expression profile in Dnmt3a conditional knockout macrophages. Methods:Dnmt3a conditional knockout macrophages mRNA profiles were generated by deep sequencing,using Illumina. Results: We mapped about 20 million sequence reads per sample to the mouse genome, identified hundreds of genes with significant mRNA variation during Dnmt3a conditional knockout in macrophages.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

2 Samples

Download data: TXT

(Submitter supplied) To measure the gene expression profile in Dnmt3a-knockdown macrophages

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

2 Samples

Download data: TXT

(Submitter supplied) Purpose:The purpose of this study is to detect activated or silenced genes during LPS-induced dendritic cell. Gene expression differences between two samples could be found using transcriptome profiling (RNA-seq) analysis. Methods:Mouse dendritic cells were generated from bone marrow cells in RPMI-1640 medium with recombinant mouse GM-CSF and IL-4, immature DCs were obtained before or after LPS stimulation. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

2 Samples

Download data: TXT