GEO DataSets

Analysis of A375 melanoma cells treated with small molecule MLN4924 for up to 24 hrs. MLN4924 selectively inhibits Nedd8-activating enzyme resulting in inactivation of the entire family of Cullin-RING ubiquitin ligases. Results provide insight into the molecular basis of MLN4924-induced cell death.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 5 time sets

Platform:

GPL570

Series:

GSE30531

30 Samples

Download data: CEL

(Submitter supplied) Microarrays were used to determine the change in gene expression of genes involved in the CDT1/NAE pathway

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4819

Platform:

GPL570

30 Samples

Download data: CEL

(Submitter supplied) CLL cells obtained from patients with CLL were treated with MLN4924 to determine whether NFkB transcription targets were affected by the drug.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

22 Samples

Download data: TXT

(Submitter supplied) The transcriptional profile of the human multiple myeloma (MM) cell line MM.1S treated with MLN4924 vs control MM.1S cells was characterized by oligonucleotide microarray analysis, using the human U133 plus 2.0 Affymetrix GeneChip, according to previously described protocols for total RNA extraction and purification; cDNA synthesis; in vitro transcription reaction for production of biotin-labeled cRNA; hybridization of cRNA with U133plus2.0 Affymetrix gene chips; and scanning of image output files. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

4 Samples

Download data: CEL

(Submitter supplied) Human DNA Damage Signaling Pathway RT2 Profiler Array Kit (Qiagen, Valencia, CA) was used to profile the expression of key genes involved in the DDR network as per the manufacturer’s instructions.

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL21406

4 Samples

Download data: TXT