GEO DataSets

Analysis of macrophages from C57BL/6.MOLFc4(51Mb)-Ldlr-/- mice. This model harbors an atherosclerosis susceptibility locus and the region homologous to the human 9p21 locus associated with coronary artery disease. Results provide insight into the molecular basis of increased atherosclerotic risk.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL9734

Series:

GSE24342

20 Samples

Download data: CEL

(Submitter supplied) Common genetic variants in a 58-kilobase (kb) region of chromosome 9p21, near the CDKN2A/B cell proliferation inhibitor genes, are strongly associated with coronary artery disease (CAD). We previously reported a congenic mouse model harboring an atherosclerosis susceptibility locus in a region of homology with the human 9p21 locus. We now report markedly decreased Cdkn2a (cyclin-dependent kinase inhibitor 2a) mRNA expression in macrophages and increased circulating levels of Ly6Chigh inflammatory monocytes in congenic mice compared to controls. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4527

Platform:

GPL9734

40 Samples

Download data: CEL

(Submitter supplied) We have applied single-cell RNA sequencing as an unbiased profiling strategy to interrogate and classify aortic macrophage heterogeneity at the single-cell level in atherosclerosis.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL17021 GPL19057

5 Samples

Download data: CSV, H5, TAR, TXT

(Submitter supplied) The chromosome 9p21 locus comprises several tumor suppressor genes including MTAP, CDKN2A and CDKN2B, and its homo- or heterozygous deletions are associated with reduced survival in multiple cancer types. We report that mice with germline monoallelic deletion or induced biallelic deletion of the 9p21-syntenic locus (9p21s) developed fatal myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN)-like disease associated with aberrant trabecular bone formation and/or fibrosis in the bone marrow (BM). more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Other

Platform:

GPL24247

16 Samples

Download data: MTX, ROBJ, TSV

(Submitter supplied) Well-defined, closed breeding populations coupled with excessive disease predispositions among purebred domestic dog breeds offer unique advantages to genetic studies of disease susceptibility. Advantages offered by canine population substructure, combined with similarity to human disease in terms of clinical presentation and response to treatment, make the dog a particularly attractive system for finding genes associated with cancer. more...

Organism:

Canis lupus familiaris

Type:

SNP genotyping by SNP array

Platform:

GPL15578

474 Samples

Download data: TXT