GEO DataSets

Analysis of peripheral blood from men with non-metastatic prostate cancer (PC) on days 1, 7, 14, 21, 42 of external beam radiation therapy (EBRT), and at 30 days post-EBRT. Fatigue is a common side effect of EBRT. Results provide insight into molecular basis of fatigue in men with PC during EBRT.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 20 individual, 2 protocol, 8 time sets

Platform:

GPL570

Series:

GSE30174

80 Samples

Download data: CEL

(Submitter supplied) The etiology behind cancer-related fatigue (CRF) is currently unknown. The physiological mechanisms of CRF are based on limited evidence that genetic factors, energy expenditure, metabolism, aerobic capacity, and the individual's immune response to inflammation are responsible for the experience of CRF. Gene expression profiling using microarray analysis from white blood cells of men with non-metastatic prostate cancer shows significant, differential expression of 463 probesets during localized external beam radiation therapy (EBRT). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4395

Platform:

GPL570

80 Samples

Download data: CEL

(Submitter supplied) Parkinson’s disease (PD) progresses relentlessly and affects five million people worldwide. Laboratory tests for PD are critically needed for developing treatments designed to slow or prevent progression of the disease. We performed a transcriptome-wide scan in 105 individuals to interrogate the molecular processes perturbed in cellular blood of patients with early-stage PD. The molecular marker here identified is strongly associated with risk of PD in 66 samples of the training set (third tertile cross-validated odds ratio of 5.7 {P for trend 0.005}). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2519

Platform:

GPL96

105 Samples

Download data: CEL

Analysis of blood of 50 patients predominantly with early-stage Parkinson’s disease (PD). Results provide insight into the molecular processes perturbed in the cellular blood of patients with early-stage PD.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL96

Series:

GSE6613

105 Samples

Download data: CEL

(Submitter supplied) Importance. Biological markers of Parkinson’s disease are essential for achieving disease modification. Objective. To determine the association of SNCA blood transcript levels with prevalence of Parkinson’s disease. Background. The SNCA locus is preferentially transcribed in neurons and blood cells. Non-coding genetic variants and neuronal aggregates of α-synuclein protein associate this locus with sporadic Parkinson’s disease and suggest a potential role for abnormal SNCA transcription in the disease mechanism. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

142 Samples

Download data: TXT

(Submitter supplied) The pre-synaptic protein α-synuclein is a key player in the pathogenesis of Parkinson's disease. Together with accumulation and missfolding of α-synuclein protofibrils serve as seed structures for the aggregation of numerous proteins in the cytoplasm of neuronal cells, the so-called Lewy bodies. Furthermore, missense mutations in the SNCA gene and gene multiplications lead to autosomal dominant forms of familiar PD. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

6 Samples

Download data: CEL, CHP

(Submitter supplied) Alpha synuclein (SNCA) has been linked to neurodegenerative diseases (synucleinopathies) that include Parkinson’s disease (PD). Although the primary neurodegeneration in PD involves nigrostriatal dopaminergic neurons, more extensive yet regionally selective neurodegeneration is observed in other synucleinopathies. Furthermore, SNCA is ubiquitously expressed in neurons and numerous neuronal systems are dysfunctional in PD. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

2 Samples

Download data: CEL, CHP

(Submitter supplied) Parkinson’s disease (PD), the second most frequent neurodegenerative disorder at old age, can be caused by elevated expression, or the A53T mutation, of the presynaptic protein alpha-synuclein (SNCA). PD is characterized pathologically by the preferential vulnerability of the dopaminergic nigrostriatal projection neurons. Here, we used two mouse lines overexpressing human A53T-SNCA around ages 6 and 18 months and studied striatal dysfunction in the absence of neurodegeneration to understand early disease mechanisms. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

54 Samples

Download data: CEL