GEO DataSets

Analysis of pectoralis muscle from 4 month-old, wildtype/mdx chimeric males. Chimeras were created by injecting WT ESCs into mdx mutant blastocysts; injected blastocysts developed in the uterus of pseudopregnant females. Results provide insight into molecular basis of WT ESC rescue of mdx mice.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 5 genotype/variation sets

Platform:

GPL8321

Series:

GSE12580

5 Samples

Download data: CEL

(Submitter supplied) Duchenne muscular dystrophy (DMD) is an incurable neuromuscular degenerative disease, caused by a mutation in the dystrophin gene. Mdx mice recapitulate DMD features. Here we show that injection of wild-type (WT) embryonic stem cells (ESCs) into mdx blastocysts produces mice with improved pathology. A small fraction of WT ESCs incorporates into the mdx mouse nonuniformly to upregulate protein levels of dystrophin in the skeletal muscle. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4199

Platform:

GPL8321

5 Samples

Download data: CEL

(Submitter supplied) Despite over 3,000 articles published on dystrophin in the last 15 years, the reasons underlying the progression of the human disease, differential muscle involvement, and disparate phenotypes in different species are not understood. The present experiment employed a screen of 12,488 mRNAs in 16-wk-old mouse mdx muscle at a time when the skeletal muscle is avoiding severe dystrophic pathophysiology, despite the absence of a functional dystrophin protein. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS236

Platform:

GPL81

10 Samples

Download data: CEL

Examination of mdx mouse, Duchenne muscular dystrophy model. 16 week regenerating mdx muscle analyzed in search for salvage pathways that maintain skeletal muscle integrity in the absence of functional dystrophin protein.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL81

Series:

GSE466

10 Samples

Download data: CEL