GEO DataSets

Analysis of P4 ovaries of Sprague-Dawley females exposed to growth factors. Ovarian primordial follicles are critical for female reproduction and comprise a finite pool of gametes arrested in development. Results provide insight into molecular mechanisms underlying primordial follicle development.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 10 agent sets

Platform:

GPL6247

Series:

GSE20324

44 Samples

Download data: CEL

(Submitter supplied) Ovarian primordial follicles are critical for female reproduction and comprise a finite pool of gametes arrested in development. A systems biology approach was used to identify regulatory gene networks essential for primordial follicle development. Transcriptional responses to eight different growth factors known to influence primordial follicles were used to construct a bionetwork of regulatory genes involved in primordial follicle development. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS4048

Platform:

GPL6247

44 Samples

Download data: CEL

(Submitter supplied) The assembly of the developmentally arrested primordial follicle and subsequent transition to the primary follicle are poorly understood processes critical to ovarian biology. Abnormal primordial follicle development can lead to pathologies such as premature ovarian failure. The current study used a genome-wide expression profile to investigate primordial follicle assembly and development. Rat ovaries with predominantly unassembled, primordial, or primary follicles were obtained. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3006

Platform:

GPL85

6 Samples

Download data: CEL

Analysis of ovaries with unassembled, primordial, and primary follicles. Abnormal primordial follicle development can cause pathologies such as premature ovarian failure. Results provide insight into molecular mechanisms underlying primordial follicle assembly and transition to primary follicles.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 development stage, 3 protocol sets

Platform:

GPL85

Series:

GSE9300

6 Samples

Download data: CEL

(Submitter supplied) Primordial follicle assembly is the process by which ovarian primordial follicles are formed. During follicle assembly oocyte nests break down and a layer of pre-granulosa cells surrounds individual oocytes to form primordial follicles. The pool of primordial follicles formed is the source of oocytes for ovulation during a female’s reproductive life. Complex networks of cellular signaling and gene expression are essential for any biological process. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

27 Samples

Download data: CEL

(Submitter supplied) Primordial follicle assembly is a process that occurs in the embryonic or early post natal ovary in which oocyte nests break down to form individual primordial follicles. The size of this initial pool of primordial follicles in part determines the reproductive lifespan of the female. Connective tissue growth factor (CTGF) was identified as a potential regulatory candidate for this process in a previous microarray analysis of follicle development. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

6 Samples

Download data: CEL

(Submitter supplied) The current study was designed to investigate the actions of Anti-Müllerian Hormone (AMH) on primordial follicle assembly. Ovarian primordial follicles develop from the breakdown of oocyte nests during fetal development for the human and immediately after birth in rodents. AMH was found to inhibit primordial follicle assembly, decrease the initial primordial follicle pool size and promote the persistence of small oocyte nests in a rat ovarian organ culture. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

6 Samples

Download data: CEL

(Submitter supplied) Female fertility is determined in part by the size and development of the primordial follicle pool. The current study investigates the role of glial cell-line derived neurotrophic factor (GDNF) in the regulation of primordial follicle development in the ovary. Ovaries from four-day old female rat pups were maintained in organ culture for ten days in the absence (control) or presence of GDNF or kit ligand/stem cell factor (KL). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

4 Samples

Download data: CEL

(Submitter supplied) The oocytes found within the primordial follicles of mammalian ovaries remain quiescent for months to years until they receive the appropriate signals to undergo the primordial to primary follicle transition and initiate folliculogenesis. The molecular mechanisms and extracellular signaling factors that regulate this process remain to be fully elucidated. The current study investigates the mechanisms utilized by anti-Müllerian hormone (AMH; i.e. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3199

Platform:

GPL1355

4 Samples

Download data: CEL

Analysis of postnatal day 4 ovaries cultured with anti-Mullerian hormone (AMH) for 10 days. AMH is an extracellular signaling molecule that inhibits the primordial to primary follicle transition in ovary. Results provide insight into molecular mechanisms underlying primordial follicle development.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL1355

Series:

GSE10557

4 Samples

Download data: CEL

(Submitter supplied) Follicle assembly is the process by which groups or ‘nests’ of oocytes break down to form primordial follicles. The size of the primordial follicle pool is the major determinant of the reproductive lifespan of a female. Previously, progesterone (P4) has been shown to inhibit follicle assembly, while tumor necrosis factor alpha (TNF-alpha) has been shown to promote the apoptosis that is necessary for follicle assembly. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2783

Platform:

GPL1355

4 Samples

Download data: CEL

Analysis of cultured neonatal ovaries treated with progesterone for 2 days. In the early postnatal period, groups of oocytes break down to form primordial follicles. This process is called follicle assembly. Results provide insight into the role of progesterone in follicle assembly.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL1355

Series:

GSE8238

4 Samples

Download data: CEL

(Submitter supplied) Women are born with millions of primordial follicles which gradually decrease with increasing age and this irreversible supply of follicles completely exhausts at menopause. The fertility capacity of women diminishes in parallel with aging. The mechanisms for reproductive aging are not fully understood. In our recent work we observed a decline in BRCA1 mediated DNA repair in aging rat primordial follicles. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

6 Samples

Download data: TXT

(Submitter supplied) Neurotrophins are growth factors that are known to have a role in promoting cell survival and differentiation. The focus of the current study is to examine the role of neurotrophins in regulating ovarian primordial follicle development. Ovaries from 4-day old rats were placed into organ culture and cultured for 10 days in the absence or presence of neurotrophin-3 (NT3), brain-derived neurotrophic factor (BDNF), or nerve growth factor (NGF). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3624

Platform:

GPL1355

6 Samples

Download data: CEL

Analysis of 4 day old ovaries cultured in the presence of neurotrophin-3 (NT3) for 2 days. Neurotrophins are growth factors involved in promoting cell survival and differentiation. Results provide insight into the role of NT3 in ovarian primordial follicle development.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL1355

Series:

GSE20358

6 Samples

Download data: CEL

(Submitter supplied) The early (primordial), middle and last stage ovarian follicles gestate important functionally changes during the whole growth phase. The primordial follicles establish the resting pool and keep silent until initiated growth. The middle stage follicles are to be destined for dominance or atresia. And the last stage fllicles develop till ovulation.We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

6 Samples

Download data

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Other; Expression profiling by array

Platforms:

GPL7202 GPL11002

20 Samples

Download data: TXT

(Submitter supplied) Long-term reproductive ability in mammalian females is sustained by the successive consumption of the finite pool of primordial follicles, the most primitive ovarian follicles that arise from cystic-oocytes during oogenesis. However, mechanisms underlying the formation of primordial follicles are largely unknown. Here we show that dynamic conversion of RNA-regulatory proteins precedes the formation of primordial follicles in mice. more...

Organism:

Mus musculus

Type:

Other

Platform:

GPL11002

2 Samples

Download data: TSV

(Submitter supplied) Elavl2 knocout female mice show oocyte loss-phenotype shortly after birth. To reveal the involvement of Elavl2 in oogenic gene expression, embryonic and newborn ovaries were subjected to microarray analysis

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

18 Samples

Download data: TXT

(Submitter supplied) Development of ovarian follicles is controlled at the molecular level by several gene products whose precise expression leads to regression or ovulation of follicles. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression through sequence-specific base pairing with target messenger RNAs (mRNAs) causing translation repression or mRNA degradation. The aim of this study was to identify miRNAs expressed in ovarian follicles, localize their expression within the theca and/or granulosa layers and their putative target genes/pathways that are involved in bovine ovarian follicle development. more...

Organism:

Bos taurus

Type:

Non-coding RNA profiling by array

Platform:

GPL18422

24 Samples

Download data: TXT