Similar studies for GEO DataSets (Select 4026) - GEO DataSets

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Items: 4

Select item 40261.

High-density lipoproteins effect on pancreatic β cells subjected to apoptotic stimuli

Analysis of pancreatic β-TC3 insulinoma cell line subjected to serum deprivation in the presence of high-density lipoproteins (HDLs). Results provide insight into the molecular mechanisms underlying the HDL protective effect on pancreatic β-cells in response to stress.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 protocol, 2 stress sets

Platform:: GPL1261
Series:: GSE17647
24 Samples

Download data: CEL

DataSet

Accession:: GDS4026

ID:: 4026

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000176472.

Involvement of 4E-BP1 in the protection induced by HDLs on pancreatic beta cells

(Submitter supplied) High-density lipoproteins (HDLs) protect pancreatic β cells against apoptosis. This property might be related to the increased risk to develop diabetes in patients with low HDL blood levels. However, the mechanisms by which HDLs protect β cells are poorly characterized. Here we use a transcriptomic approach to identify genes differentially modulated by HDLs in β cells subjected to apoptotic stimuli.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4026
Platform:: GPL1261
24 Samples

Download data: CEL

Series

Accession:: GSE17647

ID:: 200017647

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001316683.

(Submitter supplied) Eukaryotic translation initiation factor 4E (eIF4E)–binding protein 1 (4E-BP1) inhibits cap-dependent translation in eukaryotes by competing with eIF4G for an interaction with eIF4E. Phos-phorylation at Ser-83 of 4E-BP1 occurs during mitosis through the activity of cyclin-dependent kinase 1 (CDK1)/cyclin B rather than through canonical mTOR kinase activity. Here, we investi-gated the interaction of eIF4E with 4E-BP1 or eIF4G during interphase and mitosis. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
20 Samples

Download data: TXT

Series

Accession:: GSE131668

ID:: 200131668

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000259044.

Expression data from discodermolide sensitive and resistant cell lines

(Submitter supplied) Discodermolide treatment of A549 results in senescence. We compared cells resistant to disco-induced senescence to those that are sensitive to senescence induction. We also examined the gene expression of resistant (AD32) cells overexpressing 4E-BP1, a protein known to restore sensitivity to discodermolide in these cells.