GEO DataSets

Analysis of optic nerve head and retina from 10.5-month-old, DBA/2J females at various stages of glaucoma. The DBA/2J strain is an inherited, later-onset, complex, and chronic model of glaucoma. Results provide insight into molecular mechanisms underlying the early stages of glaucoma.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 age, 5 disease state, 2 strain, 2 tissue sets

Platform:

GPL1261

Series:

GSE26299

108 Samples

Download data: CEL

(Submitter supplied) In this study that was specifically designed to identify early stages of glaucoma in DBA/2J mice, we used genome-wide expression profiling and a series of computational methods. Our methods successfully subdivided eyes with no detectable glaucoma by conventional assays into molecularly defined stages of disease. These stages represent a temporally ordered sequence of glaucoma states. Using an array of tools, we then determined networks and biological processes that are altered at these early stages. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3899

Platform:

GPL1261

108 Samples

Download data: CEL, TXT

(Submitter supplied) Glaucoma is a common ocular disorder that is a leading cause of blindness worldwide. It is characterized by the dysfunction and loss of retinal ganglion cells (RGCs). Although many studies have implicated various molecules in glaucoma, no mechanism has been shown to be responsible for the earliest detectable damage to RGCs and their axons in the optic nerve. Here, we show that the leukocyte transendothelial migration pathway is activated in the optic nerve head at the earliest stages of disease in an inherited mouse model of glaucoma. more...

Organism:

Mus musculus

Type:

Expression profiling by array; Third-party reanalysis

Platform:

GPL1261

49 Samples

Download data: CEL, TXT

(Submitter supplied) RNA-seq analysis from young and pre-glaucomatous DBA/2J retinal ganglion cells and control (age and sex-matched, D2-Gpnmb+) retinal ganglion cells

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

61 Samples

Download data: CSV

(Submitter supplied) Glaucoma, a multifactorial neurodegenerative disease characterized by progressive loss of retinal ganglion cells and their axons in the optic nerve, is a leading cause of irreversible vision loss. Intraocular pressure (IOP) is a risk factor for axonal damage, which initially occurs at the optic nerve head (ONH). Complex cellular and molecular mechanisms involved in the pathogenesis of glaucomatous optic neuropathy remain unclear. more...

Organism:

Felis catus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17081

16 Samples

Download data: GTF, TXT