GEO DataSets

Analysis of percutaneous needle liver biopsies from 10 people with type 2 diabetes (T2D) and 7 normal subjects. The liver has a central role in glucose homeostasis and is a major site of secretory protein production. Results provide insight into the role of hepatokines in T2D insulin resistance.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 2 gender sets

Platform:

GPL570

Series:

GSE23343

17 Samples

Download data: CEL

(Submitter supplied) The liver may regulate glucose homeostasis by modulating the sensitivity/resistance of peripheral tissues to insulin, by way of the production of secreted proteins, termed hepatokines. To identify hepatic secretory proteins involved in insulin resistance, we performed liver biopsies in humans with or without type 2 diabetes and conducted a comprehensive analysis of gene expression profiles.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3883

Platform:

GPL570

17 Samples

Download data: CEL

(Submitter supplied) Regulation of gene expression is an important aspect of insulin’s physiological action, however, most studies rely on in vitro systems or pharmacological doses of insulin. Here, we demonstrate that under euglycemic-clamp conditions, physiological levels of insulin regulate over 1500 transcripts in muscle and 1000 transcripts in liver. These include expected pathways related to glucose and lipid utilization, mitochondrial function and autophagy in muscle, and glucose production and steroidogenesis in liver, as well as unexpected pathways, such as mRNA splicing, chromatin remodeling, and regulation of hepatocyte nuclear factors. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

72 Samples

Download data: TXT