GEO DataSets

Analysis of lung tumor cells and transgenic but morphologically unaltered lung cells, both harvested from SP-C/c-raf transgenics. Normal lung from non-transgenic littermates also examined. Results provide insight into molecular mechanisms underlying the progression from lung dysplasia to cancer.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 7 age, 3 disease state, 2 gender, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE14277

15 Samples

Download data: CEL, CHP

(Submitter supplied) Lung cancer is a leading cause of deaths in the world. There is a need to improve an understanding of mechanisms of malignant transformation and to develop genetic markers of disease for better and targeted therapies. Here, we report findings with a transgenic disease model where targeted expression of c-raf to respiratory epithelium induced adenocarcinomas. Specifically, by use of laser microdissection we harvested either tumor or transgenic and non-transgenic but otherwise morphologically unaltered cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3826

Platform:

GPL1261

15 Samples

Download data: CEL, CHP

(Submitter supplied) Background: Lung cancer is a multistage process with poor prognosis and high morbidity. Importantly, the genetics of dysplasia, a facultative cancer, at the edge of malignant transformation is unknown. Results: We employed laser microdissection to harvest dysplastic as opposed to transgenic but otherwise morphologically unaltered epithelium and compared findings to non-transgenic lung. We then employed microarrays to search genome wide for gene regulatory networks. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3825

Platform:

GPL1261

15 Samples

Download data: CEL, CHP

Analysis of dysplastic lung cells and transgenic but morphologically unaltered lung cells, both harvested from SP-C/c-raf transgenics. Normal lung from non-transgenic littermates also examined. Results provide insight into molecular mechanisms underlying an early stage of lung cancer development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age, 3 disease state, 2 gender, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE13963

15 Samples

Download data: CEL, CHP

(Submitter supplied) To study a complex network of gene expression changes underlying c-Myc-triggered carcinogenesis in lung we performed oligonucleotide array analysis of solid lung adenocarcinomas which developed in transgenic mice due to constitutive expression of c- Myc in alveolar type II epithelial cells and compared them with the non-transgenic lung as a control. The microarray analysis yielded 162 up regulated and 301 down regulated genes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

14 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; synthetic construct

Type:

Non-coding RNA profiling by array

Platforms:

GPL8786 GPL13493

42 Samples

Download data: CEL, TXT

(Submitter supplied) In this study we analyzed the expression of miRNAs in the lungs of SP-C/c-raf transgenic mice. The transgene is under the transcriptional control of the surfactant protein C (SP-C) promoter and consists of the oncogenically activated NH2-terminal deletion mutant c-Raf-1-BxB. Overall this study aims at identifying miRNAs regulated in precursor lesions of lung cancer.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL13493

24 Samples

Download data: TXT

(Submitter supplied) In this study we analyzed the expression of miRNAs in the lungs of SP-C/c-raf transgenic mice. The transgene is under the transcriptional control of the surfactant protein C (SP-C) promoter and consists of the oncogenically activated NH2-terminal deletion mutant c-Raf-1-BxB. Overall this study aims at identifying miRNAs regulated in precursor lesions of lung cancer.

Organism:

Mus musculus; synthetic construct

Type:

Non-coding RNA profiling by array

Platform:

GPL8786

18 Samples

Download data: CEL

(Submitter supplied) The transcriptional regulator c-Myc is the most frequently deregulated oncogene in human tumors. Targeted overexpression of this gene in mice results in distinct types of lung adenocarcinomas. By using microarray technology, alterations in the expression of genes were captured based on a female transgenic mouse model in which, indeed, c-Myc overexpression in alveolar epithelium results in the development of bronchiolo-alveolar carcinoma (BAC) and papillary adenocarcinoma (PLAC). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3321

Platform:

GPL1261

8 Samples

Download data: CEL

Analysis of cancerous lungs of transgenics overexpressing the c-Myc proto-oncogene in their alveolar epithelia. This overexpression results in bronchiolo-alveolar carcinoma and papillary adenocarcinoma. Results provide insight into the molecular mechanisms by which c-Myc effects tumorigenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL1261

Series:

GSE10954

8 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Methylation profiling by array; Expression profiling by array

Platforms:

GPL6884 GPL8490

289 Samples

Download data

(Submitter supplied) The independent population of lung adenocarcinoma and adjacent non-tumor lung used for verification of the EDRN/Canary Foundation study

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL8490

55 Samples

Download data: TXT

(Submitter supplied) Gene expression profiling of 60 lung adenocarcinoma tumors and their matched histologically normal adjacent lung tissue samples were analyzed using Illumina HumanWG-6 v3.0 expression beadchip. We integrated these data with DNA methylation profiles of the same samples to identify potential DNA methylation regulated genes. Lung cancer is the leading cause of cancer death worldwide and adenocarcinoma is its most common histological subtype. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6884

116 Samples

Download data: TXT

(Submitter supplied) Lung cancer is the leading cause of cancer death worldwide and adenocarcinoma is its most common histological subtype. Clinical and molecular evidence indicates that lung adenocarcinoma is a heterogeneous disease, which has important implications for treatment. Here we performed genome-scale DNA methylation profiling using the Illumina Infinium HumanMethylation27 platform on 59 matched lung adenocarcinoma/non-tumor lung samples, with genome-scale verification on an independent set of tissues. more...

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL8490

118 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of human lung minimally invasive adenocarcinoma cells comparing control lepidic growth (LG) cell pool with micro-invasion (MI) cell pool.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5639

1 Sample

Download data: GPR

(Submitter supplied) Global gene expression data were generated from cultured non small cell lung cancer cell lines (NSCLC), normalized using MAS 5.0, filtered and used to predict response of cells to EGFR inhibition

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

48 Samples

Download data: CEL

(Submitter supplied) MicroRNAs are critical mediators of stem cell pluripotency, differentiation and malignancy. Limited information exists regarding microRNA alterations that facilitate initiation and progression of human lung cancers. In this study, array techniques were used to evaluate microRNA expression in normal human respiratory epithelia and lung cancer cells cultured in the presence or absence of cigarette smoke condensate (CSC). more...

Organism:

Homo sapiens

Type:

Other

Platform:

GPL16382

8 Samples

Download data: TXT

(Submitter supplied) Purpose: DNA methylation alterations are early events in tumorigenesis and important in the regulation of gene expression in cancer cells. Lung cancer has in general a poor prognosis, and a deeper insight into the epigenetic landscape in lung adenocarcinoma tumors and its prognostic implications is needed. Experimental Design: We determined whole-genome DNA methylation profiles of 164 lung adenocarcinoma samples and 19 samples of matched normal lung tissue samples using the Illumina Infinium 450K array [GSE66836]. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL14550

121 Samples

Download data: TXT

(Submitter supplied) Purpose: DNA methylation alterations are early events in tumorigenesis and important in the regulation of gene expression in cancer cells. Lung cancer has in general a poor prognosis, and a deeper insight into the epigenetic landscape in lung adenocarcinoma tumors and its prognostic implications is needed. Experimental Design: We determined whole-genome DNA methylation profiles of 164 lung adenocarcinoma samples and 19 samples of matched normal lung tissue samples using the Illumina Infinium 450K array. more...

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL13534

183 Samples

Download data: IDAT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:

GPL6947 GPL4723

150 Samples

Download data: GPR