GEO DataSets

Analysis of epithelium and stroma cells in normal and invasive breast cancer tissues. Information on the role that stroma tissues have on the growth and progression of cancer is limited.Results provide insights into the molecular basis of cancer invasion and metastasis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 cell type, 2 tissue sets

Platform:

GPL571

Series:

GSE10797

66 Samples

Download data: CEL

(Submitter supplied) The molecular basis of breast cancer invasion and metastasis is not well understood. Our objective was to analyze transcriptome differences between stromal and epithelial cells in normal breast tissue and invasive breast cancer to define the role stroma plays in invasion. Total RNA was isolated from epithelial and stromal cells that were laser captured from normal breast tissue (n=5) and invasive breast cancer (n=28). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3324

Platform:

GPL571

66 Samples

Download data: CEL

(Submitter supplied) Primary and metastatic tumor growth induce host tissue responses that are believed to support tumor progression. Understanding the molecular changes within the tumor microenvironment during tumor progression may therefore be relevant not only for discovering potential therapeutic targets but also for identifying putative molecular signatures that may improve tumor classification and predict clinical outcome. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2443

Platform:

GPL4371

10 Samples

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Analysis of laser-microdissected stromal cells from prostate intraepithelial neoplasias and invasive prostate tumors. Results provide insight into the response of stromal cells to tumor invasion.

Organism:

Mus musculus

Type:

Expression profiling by array, log2 ratio, 2 disease state sets

Platform:

GPL4371

Series:

GSE5945

10 Samples

Download data

(Submitter supplied) To obtain insight into the molecular basis of ductal carcinoma in situ (DCIS) and its progression by infiltrating surrounding tissue, we have performed cellular-based gene expression analysis of pure DCIS and DCIS with co-existing invasive ductal carcinoma (IDC) and compared the histological and molecular aspects between these morphologically identical lesions seeking to find key genes involved in DCIS progression. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1930

60 Samples

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(Submitter supplied) Analysis of differentially expressed genes from dissected whole tissue and laser capture microdissected colorectal cancer tissue samples The analysis, in colorectal cancer tissues, of compartmental and whole tissue expression profiles as well as the significantly active pathways that were differentially deregulated between the epithelial and stromal compartments when compared alongside that of whole tissue dissection

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6104

110 Samples

Download data: TXT

(Submitter supplied) Background: Tumoral masses are not only composed of malignant cells, but also enclose a more or less ample stromal micromilieu, which has been shown to influence the cancer cell behaviour. As aging induces accumulation of senescent cells in the body, this micromilieu is thought to be different in cancers occurring in old patients compared to the younger counterparts. More specifically, senescence-related fibroblastic features, such as the Senescence Associated Secretory Profile (SASP) and the induction of Autophagy, are suspected to stimulate tumor growth and progression. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

17 Samples

Download data: CEL

(Submitter supplied) Tumor epithelium and surrounding stromal cells were isolated using laser capture microdissection of human breast cancer to examine differences in gene expression based on tissue types from inflammatory and non-inflammatory breast cancer Keywords: LCM

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS3096 GDS3097

Platform:

GPL96

95 Samples

Download data: CEL

Analysis of tumor epithelia from patients with inflammatory breast cancer (IBC) and invasive non-IBC. This is part of a study that also examines the expression profiles of stromata surrounding tumors. Results provide insight into the contribution of the tumor component to the pathogenesis of IBC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL96

Series:

GSE5847

48 Samples

Download data: CEL

Analysis of stromata surrounding tumors from patients with inflammatory breast cancer (IBC) and invasive non-IBC. This is part of a study that also examines the expression profiles of tumors. Results provide insight into the contribution of the tumor stroma component to the pathogenesis of IBC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL96

Series:

GSE5847

47 Samples

Download data: CEL