GEO DataSets

Analysis of interleukin-10 (IL-10)-deficient macrophages at various time points up to 30 minutes following co-stimulation with lipopolysaccharide (LPS) and IL-10. LPS elicits an inflammatory response. Results provide insight into molecular mechanisms underlying the anti-inflammatory effect of IL-10.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 3 time sets

Platform:

GPL1261

Series:

GSE9509

18 Samples

Download data: CEL

(Submitter supplied) IL-10 regulates anti-inflammatory signaling via the activation of STAT3, which in turn controls the induction of a gene expression program whose products execute inhibitory effects on pro-inflammatory mediator production. Here we show that IL-10 induces the expression of an ETS family transcriptional repressor, ETV3 and a helicase family co-repressor, SBNO2 (Strawberry notch homolog 2) in mouse and human macrophages. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3190

Platform:

GPL1261

18 Samples

Download data: CEL

(Submitter supplied) Changes in mouse liver mRNA profiles following intraperitoneal cytokine injection. Either interferon-gamma-/-, albumin-cre(-) Socs3(w/fl) mice, or albumin-cre(+) Socs3(-/fl) mice were injected with either phosphate-buffered saline, interferon-gamma, or interfeukin-6, and livers taken after 4h. Keywords = Socs3, interferon gamma, interleukin-6, il6, liver, suppressor of cytokine signalling 3 Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS280

Platform:

GPL81

12 Samples

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Liver mRNA profiles following intraperitoneal cytokine injection. Strains interferon gamma -/-, albumin-cre(-) Socs3(w/fl) and albumin-cre(+) Socs3(-/fl) injected with either PBS, interferon gamma, or interleukin 6, and liver examined at 4 hours.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 agent, 3 strain sets

Platform:

GPL81

Series:

GSE369

12 Samples

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(Submitter supplied) Effects of SOCS3 on the transcriptional response of bone marrow-derived macrophages to IL-6. Fetal liver cells from SOCS3+/+ or SOCS3-/- embryos were used to reconstitute recipient mice. Donor derived bone marrow from these mice was differentiated to macrophages. Macrophages were either unstimulated, or stimulated for 100 or 400 minutes with 10 ng/ml IL-6. Keywords = macrophage, SOCS3, IL-6, interferon Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS325

Platform:

GPL81

17 Samples

Download data: CEL

Bone marrow-derived macrophages from mice that had received fetal liver cells from SOCS3+/+ or SOCS3-/- embryos analyzed. Macrophages either unstimulated, or stimulated for 100 or 400 minutes with 10 ng/ml IL-6.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 strain, 3 time sets

Platform:

GPL81

Series:

GSE411

17 Samples

Download data: CEL

(Submitter supplied) Single cell timecourse experiments demonstrated that though IL-6 and IL-10 activate STAT3, they generate different temporal patterns of activation, with IL-6 generating a transient activation of STAT3, and IL-10 generating a sustained STAT3 response. We hypothesized that these different STAT3 activation dynamics would dictate the differing cellular responses to the two cytokines.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

48 Samples

Download data: IDAT, SDF, TXT

(Submitter supplied) We report here the deep sequencing of the mRNA from peritoneal exudate cells (macrophages) purified from wildtype or Ptpn1 (PTP1B) knockout mice, either treated or untreated with IL-10. In periotenal macrophages IL-10 activates the transcription factor STAT3 to execute and anti-inflammatory gene expression programme. The tyrosine phosphatase PTPN1 targets STAT3 for dephosphorylation and leads to the deactivation of STAT3. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

8 Samples

Download data: TSV