GEO DataSets

Analysis of Caenorhabditis elegans worms 48 hours following treatment with lithium. Chronic lithium treatment increased the lifespan of this organism. Results provide insight into the molecular basis of lithium’s effect on lifespan.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, log ratio, 2 agent sets

Platform:

GPL5367

Series:

GSE8058

12 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of adult C. elegans comparing control untreated with populations exposed to 10mM LiCl. Populations treated from larval stage L4 for 48hr at 25oC. 10mM LiCl contained in the Nematode Growth Media (NGM) Keywords: Drug treatment

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Dataset:

GDS3140

Platform:

GPL5367

12 Samples

Download data: GPR

(Submitter supplied) Background: C. elegans fed with a chemical inhibitor of glucose, namely 2-deoxy-D-glucose (DOG), exhibit considerably extended life span. DOG, in contradiction to D-glucose, cannot be metabolized in the glycolytic pathway. This results in the fact that less glucose is available for ATP production, and thus makes DOG-feeding of the roundworms equivalent to glucose restriction. The RNA-seq data comprises 4 age groups (1, 5, 10 and 20 days after L4) Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

Organism:

Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13657

11 Samples

Download data: TXT

(Submitter supplied) FoxO transcription factors promote longevity across taxa. How they do so is poorly understood. In the nematode Caenorhabditis elegans, the A- and F-isoforms of the FoxO transcription factor DAF-16 extend life span in the context of reduced DAF-2 insulin-like growth factor receptor (IGFR) signaling. To elucidate the mechanistic basis for DAF-16/FoxO-dependent life span extension, we performed an integrative analysis of isoform-specific daf-16/FoxO mutants. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13657

21 Samples

Download data: TXT

(Submitter supplied) To identify DAF-16-dependent transcriptional alterations that occur in a long-lived C. elegans strain, we used cDNA microarrays and genomic analysis to identify putative direct and indirect DAF-16 transcriptional target genes. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Keywords: Logical Set

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL2653

4 Samples

Download data

(Submitter supplied) Y37A1B.5, a SELENBP1 ortholog in C. elegans modulates lifespan and stress resistance. Hence transcriptome profiling (RNA-seq) after depletion of Y37A1B.5 via RNAi was performed, aiming to identify targets that would explain these effects.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18245

6 Samples

Download data: CSV

(Submitter supplied) Transcriptional Profile of Aging in C. elegans Whole-genome analysis of gene expression during chronological aging of the worm provides a rich database of age-specific changes in gene expression and represents one way to distinguish among these models. Using a rigorous statistical model with multiple replicates, we find that a relatively small number of genes (only 164) show statistically significant changes in transcript levels as aging occurs (<1% of the genome). more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

5 related Platforms

26 Samples

Download data

(Submitter supplied) Males induce dramatic physiological changes to hermaphrodites, including a significant shortening of lifespan. We have termed this effect as male-induced demise (MID) of hermaphrodites. This experiment was performed to analyse changes in gene expression due to the presence of males. We have shown that Knock down of utx-1 ameliorates the MID. In this experiment we also examine male-induce gene expression that may be altered when knocking down expression of utx-1 via RNAi. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL200

11 Samples

Download data: CEL

(Submitter supplied) Gene expression analysis of Caenorhabditis elegans treated with siRNA of mitochondrial ribosomal protein-5, mrps-5

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL21109

8 Samples

Download data: TXT, XLSX

(Submitter supplied) We have discovered rifampicin as a glycation inhibitor, which increases life span in C elegans. In order to understand the mechanism of rifampicin action, microarray analysis was performed to study the changes in gene expression brought about by the drug.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL200

4 Samples

Download data: CEL