GEO DataSets

Analysis of lungs of C57BL/6J and DBA/2J animals at up to 26 months of age. Aging lungs of C57BL/6J and DBA/2J strains differ in physiology and morphometry. Results provide insight into the influence of genetic background on the variability of age-dependent changes in lung structure and function.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age, 2 strain sets

Platform:

GPL1261

Series:

GSE6591

15 Samples

Download data: CEL, EXP

(Submitter supplied) We hypothesize that gene expression in the aging lungs of these two strains of mice are divergent thus contributing to the disparity in the phenotypes. More specifically, (1) Aging DBA/2J mice compared to aging C57BL/6 mice are known to be accelerated in their lung physiology and morphometry; (2) C57BL/6J are known to have longer natural longevity than DBA/2J mice. In order to test these hypotheses at the gene expression level, we utilized microarray analysis to examine transcriptional differences between aging lungs of both strains of mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2929

Platform:

GPL1261

15 Samples

Download data: CEL, EXP

(Submitter supplied) Purpose: The goal of the present study is to provide an independent assessment of the retinal transcriptome signatures of the C57BL/6J (B6) and DBA/2J (D2) mice and to enhance existing microarray datasets for accurately defining the allelic differences in the BXD recombinant inbred strains. Methods: Retinas from both B6 and D2 mice (3 of each) were used for the RNA-seq analysis. Transcriptome features were examined for both strains. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

6 Samples

Download data: TXT, XLSX

(Submitter supplied) C57BL/6J (B6) and DBA/2J (D2) are two of the most commonly used inbred mouse strains in neuroscience research. However, the only currently available mouse genome is based entirely on the B6 strain sequence. Subsequently, oligonucleotide microarray probes are based solely on this B6 reference sequence, making their application for gene expression profiling comparisons across mouse strains dubious due to their allelic sequence differences, including single nucleotide polymorphisms (SNPs). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6885 GPL1261

44 Samples

Download data: CEL, TXT

(Submitter supplied) Purpose: The DBA/2J mouse is a model for secondary angle-closure glaucoma due to iris atrophy and pigment dispersion, which ultimately leads to increased intraocular pressure (IOP). We sought to correlate changes in retinal gene expression with glaucoma-like pathology by performing microarray analysis of retinal RNA from DBA/2J mice at 3 months before disease onset, and at 8 months, after IOP elevation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1728

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of retinas from strain DBA/2J with elevated intraocular pressure (IOP). A model for glaucoma, DBA/2J has mutations that lead to iris atrophy and pigment dispersion. These conditions result in increased IOP. Results provide insight into the molecular changes associated with IOP elevation.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 age, 2 disease state sets

Platform:

GPL1261

Series:

GSE3554

6 Samples

Download data: CEL

(Submitter supplied) Gene expression profiling with microarrays was used to identify genes differentially expressed in the lungs of B6 and BALB CF mice compared to non-CF littermates Keywords: disease state analysis

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1941

Platform:

GPL1261

23 Samples

Download data: CEL

Analysis of lungs of C57BL/6J (B6) or BALB/c (BALB) animals deficient for cystic fibrosis transmembrane conductance regulator (CFTR). B6 background animals have a higher propensity to develop CF lung disease. Results suggest the variable severity of CF is controlled by multiple genetic factors.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 gender, 2 genotype/variation, 2 strain sets

Platform:

GPL1261

Series:

GSE3100

23 Samples

Download data: CEL

(Submitter supplied) Strong differences in the immune response between the two mouse strains were found

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

30 Samples

Download data: TXT

(Submitter supplied) Aging is associated with progressive decline in lung function and responses to environmental stress culminating in increased incidence of lung diseases. Initial analysis of Atp8b1 (ATPase, Aminophospholipid Transporter, Class I, Type 8B, Member 1) mutant mice (on C57BL/6J background) revealed deficiency in transporter function and was associated with decreased lung function. Therefore, to further study the aging-related genes in the lungs at the molecular level, the transcriptome analysis of Atp8b1 mutant and C57BL/6J lungs were carried out at 14 M and 7_9 wks of age. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

23 Samples

Download data: CEL

(Submitter supplied) Young mice were compared to old mice (2 month vs 24 month) to determine gene changes that occur with aging in the mouse retinal pigmented epithelium/choroid of the eye. Keywords = retinal pigmented epithelium Keywords = aging Keywords = choroid Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL144 GPL145

12 Samples

Download data

(Submitter supplied) Age-related hearing loss (AHL) is the progressive loss of auditory function with aging. The DBA/2J (DBA) mice have been used as a model of AHL and undergoes progressive, age-related hearing loss by 12 weeks of age. Here we analyzed cochlear gene expression of 7-week-old and 36-week-old DBA mice using microarrays. Auditory brainstem response (ABR) analysis confrimed that severe age-related hearing loss occured in 36-week-old mice, whereas moderate hearing loss occured in 7-week-old mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3028

Platform:

GPL339

6 Samples

Download data: CEL

Analysis of cochleas of 7 and 36 week old DBA/2J animals. The DBA/2J animal suffers from age-related hearing loss (AHL), a progressive disease characterized by an age-associated loss of hair cells and spiral ganglion cells in the cochlea. Results provide insight into the molecular basis of AHL.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age, 2 disease state sets

Platform:

GPL339

Series:

GSE6045

6 Samples

Download data: CEL

(Submitter supplied) Identifying sex differences in gene expression within the brain is critical for determining why multiple neurological and behavioral disorders differentially affect males and females. Several are more common or severe in males (e.g., autism and schizophrenia) or females (e.g., Alzheimer’s disease and depression). We analyzed transcriptomic data from the mouse hippocampus of six inbred strains (129S1/SvImJ, A/J, C57BL/6J, DBA/1J, DBA/2J and PWD/Ph), to provide a perspective on differences between male and female gene expression. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

36 Samples

Download data: XLSX, XML

(Submitter supplied) Children less than 2 years of age are capable of healing large calvarial defects, whereas adults have been found to lack this endogenous ability. In this study, we used microarray analysis to compare genomewide expression patterns during active regeneration after injury with calvaria in skeletally immature and mature mice. Parietal bone defects were created in 6-day-old (juvenile) and 60-day-old (adult) mice using a 4-mm trephine bit (n = 20 mice per age group). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8077

2 Samples

Download data

(Submitter supplied) We hypothesize that gene expression in the CBs of these two strains of mice are divergent thus contributing to the disparity in the phenotypes. More specifically, (1) genes related to CB function are expressed less in the A/J mice compared to DBA/2J mice; (2) gene expression levels of morphogenic and trophic factors of the CB maybe significantly lower in the A/J mice than the DBA/2J mice. In order to test these hypotheses, we utilized microarray analysis to examine transcriptional differences between CBs of both strains of mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2466

Platform:

GPL1261

6 Samples

Download data

Comparison of carotid bodies (CBs) of A/J and DBA/2J animals. The CB is the primary hypoxic chemosensory organ. A/J animals are low responders to hypoxia, while DBA/2J animals are high responders. Results provide insight into the mechanisms regulating hypoxic sensitivity in the CB.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL1261

Series:

GSE5313

6 Samples

Download data

(Submitter supplied) 71 liver RNA samples from three mouse strains - DBA/2J, C57BL/6J and C3H/HeJ - were profiled using a custom-designed microarray monitoring exon and exon-junction expression of 1,020 genes representing 9,406 exons. Gene expression was calculated via two different methods, using the 3'-most exon probe ("3' gene expression profiling") and using all probes associated with the gene ("whole-transcript gene expression profiling"), while exon expression was determined using exon probes and flanking junction probes that spanned across the neighboring exons("exon expression profiling"). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6508

71 Samples

Download data: JPG, XML

(Submitter supplied) Aging of mice can be tracked by DNA methylation changes at specific sites in the genome. In this study, we used the Infinium Mouse Methylation BeadChip to compare such epigenetic modifications in C57BL/6 (B6) and DBA/2J (DBA) mice. There were marked differences in age-associated DNA methylation in these commonly used mouse strains. In B6 the age-associated DNA methylation revealed general age-associated hypomethylation with focused hypermethylation at CpG islands, whereas this was hardly observed in DBA mice. more...

Organism:

Mus musculus

Type:

Methylation profiling by array

Platform:

GPL31950

35 Samples

Download data: IDAT, TXT

(Submitter supplied) Lifelong murine gene expression profiles in relation to chronological and biological aging in multiple organs

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL14996

90 Samples

Download data: CEL