GEO DataSets

Analysis of mammary glands during pregnancy, lactation, and involution. Results provide insight into the molecular mechanisms regulating mammary gland development.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 development stage, 8 time sets

Platform:

GPL81

Series:

GSE8191

40 Samples

Download data: CEL, CHP

(Submitter supplied) The transition from pregnancy to lactation is a critical event in the survival of the newborn since all the nutrient requirements of the infant are provided by milk. While milk contains numerous components, including proteins, that aid in maintaining the health of the infant, lactose and milk fat represent the critical energy providing elements of milk. Much of the research to date on mammary epithelial differentiation has focused upon expression of milk protein genes, providing a somewhat distorted view of alveolar differentiation and secretory activation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2843

Platform:

GPL81

40 Samples

Download data: CEL, CHP

(Submitter supplied) 2-methoxyestradiol (2ME2) induces mammary gland differentiation through amphiregulin-EGFR mediated signaling: molecular distinctions from the mammary gland of pregnant mice.High levels of 2ME2 are observed in the late stages of pregnancy. We investigated the role of 2ME2 on normal mammary gland development. Large scale gene expression assays were performed using Affymetrix GeneChips in pursuit of detailed molecular basis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL81 GPL1261

55 Samples

Download data: CEL, XLS

(Submitter supplied) Developmental programming is the concept that environmental factors, particularly during foetal life, can alter development, metabolism and physiology of an organism and this can have consequences later in life. There is growing interest in developmental programming in livestock species, particularly effects of maternal pregnancy nutrition, which is easy to manipulate. Recent research, using a sheep model, has shown that milk production in ewe offspring may be susceptible to maternal nutritional programming, such that over nutrition (ad libitum) of the pregnant dam, compared with maintenance nutrition, may impair their first lactation performance and result in the weaning of lighter lambs. more...

Organism:

Ovis aries

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15670

15 Samples

Download data: CSV

(Submitter supplied) Five healthy Laoshan dairy goats (four years old, third lactation) from Qingdao Laoshan dairy goat primary farm (Shandong Province, China) were used. The mammary gland samples were collected surgically after general anaesthesia using Xylazine Hydrochloride injection solution (Huamu Animal Health Products Co., Ltd. China) at corresponding lactation stage, including early, peak and late lactations.

Organism:

Capra hircus

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL15473

3 Samples

Download data: TXT

(Submitter supplied) The purpose of the present study was to provide a comprehensive transcriptome profiling of mammary gland and to find the key differences in the milk production and related traits between Jersey and Kashmiri cattle. Casein and whey protein genes were found to be highly expressed throughout the lactation cycle. Largest differences in DEGs was reported between D15 and D90 with 1805 genes in Kashmiri cattle and between D15 and D250 with 3392 genes in Jersey cattle.

Organism:

Bos indicus; Bos taurus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL19172 GPL19746

17 Samples

Download data: TXT

(Submitter supplied) The molecular processes underlying human milk production and the effects of mastitic infection are largely unknown because of limitations in obtaining tissue samples. Determination of gene expression in normal lactating women would be a significant step towards understanding why some women display poor lactation outcomes. Here we demonstrate the utility of RNA obtained directly from human milk cells to detect mammary epithelial cell (MEC)-specific gene expression. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

11 Samples

Download data: CEL

(Submitter supplied) Transcript profiling was performed by Affymetrix microarray analysis and SAGE to characterize changes in gene expression in the bovine mammary gland in response to 4× versus 2× daily milking during the first week of lactation. These changes in gene expression may contribute to the increased milk production observed in response to increased milking frequency. Our results indicate that increased milking frequency alters expression of genes in the mammary gland related to increased extracellular matrix remodeling, neovascularization, metabolism, cell proliferation and apoptosis. more...

Organism:

Bos taurus

Type:

Expression profiling by array; Expression profiling by SAGE

Platforms:

GPL2112 GPL223

9 Samples

Download data: CEL

(Submitter supplied) The 24h gene expression profile in the lactating mammary gland was demonstrated using the Human Ref-8 BeadChip array (Illumina, Inc). Of the 22,184 gene transcripts on the array, 14,070 genes were consistently expressed and represented the milk fat globule transcriptome. Milk protein genes were among the most highly expressed along with genes involved in the milk syntesis processes. Keywords: time course analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6104

40 Samples

Download data: TXT